Journal of the Korean Pediatric Society 1978;21(5):389-395.
Published online May 31, 1978.
Clinical Studies on Neonatal Hepatitis.
Hong Kyu Lee, Moon Hee Lee, Dong Gwan Han, Duk Jin Yun
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
新生兒肝炎의 臨床的 觀察
李私揆, 李汶禧, 韓東觀, 尹德鎭
延世大學校 醫科大學 小兒科學敎室
Abstract
43 cases of neonatal hepatitis were clinicallt evaluated, who were admitted to the pediatric department of Severance hospital furing period from April, 1956 to Februart, 1976. The following results were obtained. There was little difference in sex incidence, and most of them were admitted at the age of 1 month to 3 months after birth. Clinical symptoms and signs on admission were jaundice(95%), hepatomegaly(95%), splenom-egaly(41%), fever(41%), and cough(20%). Clay-colored stool was found in 34 cases(79%), and jaundice was found within 6 weeks after birth in most patients. In laboratory studies, total bilirubin, SGOT, SGPT, and Al. phosphatase were all elevated, and return to normal level at 5 weeks after admission. For the precise diagnosis, needle biopsy of the liver was done in 18 cases, among which 14cases showed multinucleated giant cells in specimen, but in 4 cases, giant cells were not observed, and only intrabepatic cholestasis was seen. As complication, bronchopneumonia(9 cases), sepsis(6 cases), rickets(3 cases), and bleeding(4 cases) developed, but which did not influence the prognosis. Most patients were recovered completely, but 6 patients died during admission and 7 patients were discharged in a hopeless condition.


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