A female infant was born by spontaneous vaginal delivery at 40 weeks and 3 days of gestation with a birth weight of 3,500 g from the third pregnancy of a 38-year-old woman. The mother was G2P0A0A2 and had undergone 2 previous uncomplicated normal deliveries. Her prenatal and maternal history was unremarkable. The first 2 children are presently thriving. On the third day after delivery, this baby presented with jaundice; the total bilirubin level was 34.2 mg/dL. We started intensive phototherapy and prepared to perform an exchange transfusion to decrease the bilirubin levels. The other laboratory findings are presented in Table 1. The mother’s blood group was Rh-positive A type. Considering the aforementioned findings, indirect hyperbilirubinemia related to minor blood group incompatibility due to anti-E antibodies was diagnosed. The infant was treated with exchange transfusion and intravenous immunoglobulin and intensive phototherapy to prevent kernicterus and progression of hemolysis. Following the exchange transfusion, the total bilirubin remained elevated at 22.3 mg/dL. Eight hours after continuing intensive phototherapy, progressive gray-brown discoloration of the skin was noted (Fig. 1A). This discoloration was observed in areas that were uncovered and exposed to the intensive phototherapy light (Fig. 1A). The laboratory values observed at that point are presented in Table 1.