Journal of the Korean Pediatric Society 1972;15(5):412-415.
Published online May 31, 1972.
Comparison of Efficacy of Various Oral - Hypoglycemic Agents on Diabetes Insipidus
Heung Kyu Kim, Yang Hyun Park, En Yul Yum, Ki Bok Kim
Department of Pediatrics, Kwangju Christian Hospital
뇨붕증세 있어서 수종의 경구 저혈당제의 항 이뇨효과의 비교
김흥규, 박양현, 염은열, 김기복
광주기독병원 소아과
Abstract
The efficacy of three oral hypoglycemic agents, all sulfonylurea derivatives (Chlorpropamide, Tolbutamide and Tolazamide) were compared in the case of a 6-year-old girl suffering from diabetes insipidus. Chlorpromide was demonstrated to be the most effective, Tolbutamide slightly effective, and Tolazamide lacked antidiuretic action. Comparison of molecular structures of these agents revealed that replacement of Cl in para-position with methyl radical did not greatly influence the antidiabetic efficacy, whereas replacing the propylradical with other complex radicals markedly affects the efficacy.


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