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Recent advances in food allergen immunotherapy

Clin Exp Pediatr > Accepted Articles
DOI: https://doi.org/10.3345/cep.2023.01004    [Accepted]
Published online December 7, 2023.
Recent advances in food allergen immunotherapy
You Hoon Jeon1  , Edwin H. Kim2 
1Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hwaseong-si, Korea
2Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States
Correspondence: 
Edwin H. Kim, Email: edwinkim@email.unc.edu
Received: 24 July 2023   • Revised: 30 September 2023   • Accepted: 21 October 2023
Abstract
Food allergies can pose significant risks and profoundly impact the quality of life of children and their families, making them a major public health concern. Allergen avoidance has been the traditional mainstay of treatment; however, recent research has focused on various approaches to food allergen immunotherapy. This review summarizes the recent advancements in oral, sublingual, and epicutaneous immunotherapies, highlighting their respective advantages and disadvantages. The ultimate goal of food allergen immunotherapy is to maximize efficacy while minimizing risks, leading to the exploration of strategies such as low-dose immunotherapy and the use of biologics. When selecting candidates for immunotherapy among patients with food allergies, factors such as allergen characteristics, the likelihood of natural resolution, age, symptom severity, and impact on quality of life require consideration, and an individualized approach should be adopted to determine the most suitable treatment method.
Key Words: Food allergy, Oral immunotherapy, Sublingual immunotherapy, Epicutaneous immunotherapy


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