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The clinical picture of beingn recurrent intrahepatic cholestasis (BRIC) consists of multiple epi-
sodes of cholestatic jaundice without extrahepatic bile duct obstruction. Since first description by
Summerskill and Walshe in 1959, almost 100 patients with BRIC have been described. The mechanism
involved in the initiation and perpetution of an episode of cholestasis are unknown. Altered bile acid
metabolism has been proposed to play a... |
