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Objective : Oxygen free radicals has been reported to be the critical cellular mediators of
experimental ischemia-reperfusion renal injury. We examined the protective effect of allopurinol
(an xanthine oxidase inhibitor) on the renal damage by reperfusion in the ischemic rat kidney.
Methods : To induce renal ischemia, the Sprague-Dawley rats(weight 70-80g) were placed in a
sealed 5L jar with 8% O2-92% N2 gas mixture... |
