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Case Report
Toxic epidermal necrolysis induced by lamotrigine treatment in a child
Youngsuk Yi, Jeong Ho Lee, Eun Sook Suh
Clin Exp Pediatr. 2014;57(3):153-156.   Published online March 31, 2014

Toxic epidermal necrolysis is an unpredictable and severe adverse drug reaction. In toxic epidermal necrolysis, epidermal damage appears to result from keratinocyte apoptosis. This condition is triggered by many factors, principally drugs such as antiepileptic medications, antibiotics (particularly sulfonamide), nonsteroidal anti-inflammatory drugs, allopurinol, and nevirapine. Lamotrigine has been reported potentially cause serious cutaneous reactions, and concomitant use of valproic acid...

A case of steroid-induced psychosis in a child having nephrotic syndrome with toxic epidermal necrolysis
Sae Yoon Kim, Jae Min Lee, Yong Hoom Park
Clin Exp Pediatr. 2010;53(3):437-441.   Published online March 15, 2010
Toxic epidermal necrolysis (TEN) and Stevens–Johnson syndrome (SJS) are rare, life-threatening mucocutaneous diseases, usually attributable to drugs and infections. Corticosteroids have been used in the management of TEN for the last 30 years. This remains controversial and is still much debated. TEN can occur despite administration of high doses of systemic corticosteroids. The psychiatric side effects of corticosteroids can include...
Steroid and enalapril therapy - possible cause of toxic epidermal necrolysis
Dong Wook Kim, Da Eun Jung, Ja Wook Koo
Clin Exp Pediatr. 2006;49(3):332-336.   Published online March 15, 2006
Toxic epidermal necrolysis (TEN) is a rare, acute and life-threatening cutaneous drug reaction. TEN is characterized by the sudden onset of extensive necrosis in the epidermis and frequent mucous membrane involvement. The pathogenesis has not yet been elucidated. In addition, no particular treatment for TEN has been established. We report a case of TEN in a 14-year-old-boy, which might have...
A Case of Toxic Epidermal Necrolysis in Early Infancy
Min Seong Kim, Jeong Nyun Kim, Bang Soon Kim, Hong Joo Kim, Myung Jae Chey, Churl Young Chung
Clin Exp Pediatr. 1999;42(11):1594-1598.   Published online November 15, 1999
Toxic epidermal necrolysis(TEN) is a bullous disorder affecting mainly basal layers of epidermis by hypersensitive reaction. It is rarely reported in infants under six months of age. It can be developed by drug, infection, and vaccination, which makes it difficult to differentiate from staphylococcal scalded skin syndrome(SSSS) especially in early infancy. We report a case of TEN in a 6-week-old...
A Case of Carbamazepine-Induced Toxic Epidermal Necrolysis
Gi Chan Na, Kyung Seok Kim, Eun Gyeoung Jung, Kyyng Rae Moon, Sang Kee Park, Yeoung Bong Park
Clin Exp Pediatr. 1993;36(11):1630-1634.   Published online November 15, 1993
Drug-induced toxic epidermal necrolysis (TEN) is a bullous erythematous disease that is characterized by the appearance of scaled lesions and large sheets of pilling on the skin. A case of TEN occured in a 10 month old female patient. The characteristic skin lesions of TEN developed after oral administration of carbamazepine for a partial seizure. Thig case consists of prodrome of...
Original Article
A Case of Phenytoin Induced Toxic Epidermal Necrolysis.
Hae Joung Joung, Wea Kyoun Shin, Mee Kyung Namkung, Jae Seung Yang, Jong Soo Kim, Dong Sik Bang
Clin Exp Pediatr. 1990;33(9):1306-1311.   Published online September 30, 1990
Toxic epidermal necrolysis is a bullous erythematous disease characterized by scalding appearance of the skin. And , it is divided into drug induced, miscellaneous, idiopathic group by the etiology. We experienced a cases of Phenytoin induced toxic epidermal necrolysis. So, we presented the case and reviewed the literatures about it.
A Case of Toxic Epidermal Necrolysis.
Eun Hwa Shin, Youn Hong Choi, Ju Hong Cha, Kwang Jun Kim, Kyung Je Sung
Clin Exp Pediatr. 1988;31(8):1079-1084.   Published online August 31, 1988
Toxic Epidermal Necrolysis is uncommon disease characterized by erythema and shedding of the epidermis and mucous membrane. Mortality rates are high. The reaction is probably a drug-induced hypersensitivity phenomenon. We experienced Toxic Epidermal Necrolysis in a 4 yr old boy whose skin lesion had developed 3 days after taking medication from a drug store for common cold. Diagnosis of TEN was established by clinical...
Case Report
A Case of Toxic Epidermal Necrolysis.
Gye Ja Lee, Yong Aee Chun, Young Mi Hong, Young Min Ahn, Se Hoon Park
Clin Exp Pediatr. 1986;29(3):342-347.   Published online March 31, 1986
Toxic epidermal necrolysis appears to be a hypersensitivity phenomenon triggered by many factors: drugs, infections, vaccination, radiotherapy and malignancies. Widespread epidermal necrolysis rapidly follows blister formation at epidermal-dermal junction. The case fatality rate is approximately 25%. The disease consists of a prodrome of malaise, lethargy, and fever followed by erythema and massive bullae formation. This paper presented a case...