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Original Article
Thymopentin Therapy in Atopic Dermatitis
Geun Woong Noh, Ki Young Lee
Clin Exp Pediatr. 1998;41(9):1268-1272.   Published online September 15, 1998
Purpose : Atopic dermatitis is a chronic relapsing inflammatory skin disease that results from allergic reaction. Steroid therapy has become a major therapeutic modality for treatment of atopic dermatitis. Several immunomodulatory therapies have been tried for atopic dermatitis. In this study thymopentin therapy was performed and its clinical effects and laboratory results were evaluated. Methods : Atopic dermatitis with typical clinical...
Decrease of Plasma Th2 Cytokines by Interferon(IFN) -γ Therapy in Atopic Dermatitis
Geun Woong Noh, Woo Gill Lee, Dong Hee Cho, Ki Young Lee
Clin Exp Pediatr. 1998;41(8):1128-1134.   Published online August 15, 1998
Purpose : Atopic dermatitis is characterized by reduced IFN-γ production and increased IL-4 production. As a result, IgE production increases in atopic dermatitis. In the previous studies, it was reported that recombinant IFN-γ therapy is effective in treatment of severe atopic dermatitis. In this study, changes of plasma IFN-γ, IL-4, IL-5 and IL-10 concentration by IFN-γ therapy were studied in...
In Vitro Immunization-IV: Antibody Response of Mouse Splenocytes Grown in a Mixture of Conditioned Media, Thymocytes, and Bone Marrow Cells
Dong Soo Kim, Geun Woong Noh
Clin Exp Pediatr. 1992;35(7):902-908.   Published online July 15, 1992
We have previously reported several methods of in vitro immunization using different conditioned media, and the highest antibody titer was observed when a mixture of three conditioned media[PHA-stimulated adherent splenocytes conditioned medium (ASM-P), ASM-p-stimulated non-adherent splenocyte conditioned medium (NASM-A), ASM-P-stimulated thymocyte conditioned medium (TM-A)] was used. In this experiment, thymocytes and/or bone marrow cells was added instead of above conditioned media...
The Effec of Conditiond Media Cultued from the Thymocytes and the Splenocytes on the Regulation of Antibody Isotypes; In Vitro Immunization-III
Dong Soo Kim, Geun Woong Noh, Soon Hwan Oh
Clin Exp Pediatr. 1992;35(3):306-314.   Published online March 15, 1992
We had developed a method of in-vitro immunization to increase antibody titer using several cnditioned media which were developed from mouse splenocyts and thymocytes. Using fetal calf serum, the splenocytes of the mouse were divided into two types; adherent cells and non-adherent cells. We used PHA to stimulate the adherent cells to produce PHA-stimulated adherent cell conditioned medium (ACSM-P). Non-adherent...