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A Scientific Analysis of Changes in Hemostatic Parameters Following Cardiopulmonary

Journal of the Korean Pediatric Society 1992;35(1):34-43.
Published online January 15, 1992.
A Scientific Analysis of Changes in Hemostatic Parameters Following Cardiopulmonary
Hyoung Won Lee, You In Park, Kwang Chul Lee, Ju Won Lee, Soon Kyum Kim
Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea
심폐혈관 조성술후에 발생하는 혈소판 변화 및 출혈성 경향에 대한 연구
이형원, 박유인, 이광철, 이주원, 김순겸
고려대학교 의과대학 소아과학교실
Despite the scientific advances made in medical science, the potential for serious hemorrhagic complications remain an important problem in patients undergoing open heart surgery with extracorporeal circultation (OHSEC). Hematologic abnormalities that have been reported in association with OHSEC and that may lead to a hemorrhagic tendency include thrombocytopenia, alteration of coagulation factors, advanced fibrinolysis and inadequate neutralization of heparin. We investigated the changes in hemostatic parameters including platelet count (MPC), mean platelet volume (MPV), bleeding time (BT), prothrombin time (PT) and activated partial thromboplastin time (aPTT) in patients who underwent OHSEC. The results are summarized in the table shown below: Although there were several statistically significant changes observed in creatain parameters such as MPC, MPV, BT and aPTT, no clincially apparent hemorrgagic complications were observed.
Key Words: Cardiopulmonary bypass, Hemostatic parameter

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