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Three Cases of Brain Tumors with Bone Metastasis

Journal of the Korean Pediatric Society 1992;35(3):381-389.
Published online March 15, 1992.
Three Cases of Brain Tumors with Bone Metastasis
Eun Joo Kim1, Kyung Duk Park1, Eun Sil Dong1, Hye Jung Park1, Hong Hoe Koo1, Hee Young Shin1, Hyo Seop Ahn1, Je Geun Chi2
1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
2Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
뇌종양의 골전이 3례
김은주1, 박경덕1, 동은실1, 박혜정1, 구홍희1, 신희영1, 안효섭1, 지제근2
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 병리학교실
Medulloblastoma and primitive neuroectodermal tumor(PNET) are relatively common intracranial neoplasms in childhood. Their extracranial metastasis were thought to be rare occurrences. But they are more frequent compared to other intracranial tumors. The most frequent site of metastasis deposits in medulloblastoma is bone, and metastasis to lymph node, peritoneum, liver or lung have been reported infrequently. The authors experienced three cases of cerebellar brain tumors with bone metastasis, two were medulloblastomas and one, cerebellar PNET. They occurred 7,8 and 9 months after craniectomy and resection of tumor respectively. All cases were treated with postoperative craniospinal irradiation only. The first case died due to meningeal seeding 12 months after bone and bone marrow metastasis inspite of chemotherapy, the second was lost follow-up after recurrent bone metastasis during chemotherapy, and the third was on 7th cycles of ? drugs in one day?chemotherapy with clinical and radiological response.'
Key Words: Medulloblastoma, PNET, Bone Metastasis, Chemotherapy

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