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Hepatic Rickets in Infancy with Neonatal Hepatitis

Journal of the Korean Pediatric Society 1992;35(4):527-533.
Published online April 15, 1992.
Hepatic Rickets in Infancy with Neonatal Hepatitis
Mi Koo Kang, Eun Young Cho, Soo Jong Hong, Ki Soo Kim, Young Seo Park, Hyung Nam Moon, Chang Yee Hong
Department of Pediatrics, College of Medicine, University of Ulsan, Seoul, Korea
신생아 간염에서 발생한 구루병 6례
강미구, 조은영, 홍수종, 김기수, 박영서, 문형남, 홍창의
울산대학교 의과대학 소아과학교실
We had treated a hepatic rickets in 6 infants with neonatal hepatitis from June 1989 to August 1990 at Asan Medical Center. The results were as follows 1) Age of 6 patients were below 4 months and 4 patients were male, 2 patients were female. 2) The clinical findings were hepatosplenomegaly(5 cases), jaundice(4 cases), craniotabes (4 cases), failure to thrive(2 cases), hypocalcemiac seizure(2 cases), rachitic rosary(2 cases), hemolytic anemia(1 case), rib fracture(1 case). 3) All patients were tested cytomegalovirus IgM antibody and positive in 3 cases. 4) Radiologially, long bone showed typical rachitic findings. 5) After high dose vitamin D treatment, biochemical findings of calcium, inorganic phosphate, alkaline phosphatase and radiologic findings were improved. In conclusion we found that rickets was a common complication in neonatal hepatitis and in our series, the cause of neonatal hepatitis was cytomegalovirus infection. Therefore we should concern about cytomegalovirus infection and hepaic rickets in the patients with neonatal hepatitis.
Key Words: Neonatal hepatitis, Hepatic rickets, Cytomegalovirus

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