| Pharmacokinetics of Gentamicin and Amikacin in Korean Children with Normal Renal Function |
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Jin Young Park1, Ktung Bae Kwon1, Mee Ran Kim1, Hoan Jong Lee1, Jin Q Kim2, Wan Gyoon Shim3, Kyoung Ho Park3, Hae Lim Chung4 |
1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
2Department of Clinical Pathology, Seoul National University College of Medicine, Seoul, Korea
3Department of Pharmacy, Seoul National University, Seoul, Korea
4Department of Pediatrics, Seoul City Boramae Hospital, Seoul, Korea |
| 정상 신기능 소아 환자에서의 Gentamicin과 Amikacin의 약동학적 특성 |
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박진영1, 권경배1, 김미란1, 이환종1, 김진규2, 심완균3, 박경호3, 정혜림4 |
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 임상병리학교실
3서울대학교병원 약제부
4서울시립보라매병원 소아과 |
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| Abstract |
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We analysed retrospectively pharmacokinetic parameters of gentamicin and amikacin in 44 and 58 Korean pediatric patients, respectively, with normal renal function. Pharmacokinetic parameters were calculated from two concentrations in serum by method of Sawchuck. There was wide individual variation in peak serum concentrations of gentamicin and amikacin. Administration of the usually recommended doses yielded subtherapeutic concentration in 47% and 82%, respectevely, of patients in the peak concentrations of gentamicin and amikacin. The volumes of distribution of gentamicin and amikacin in children of over 1 year of age were 0.370.13L/kg and 0.410.13L/kg which are greater than those reported from the western countries.
We conclude that the wide individual variation and high frequency of subtherapeutic levels in the peak concentrations of gentamicin and amikacin obtained by usually recommended dosage as well as the narrow safety margin of these of these drugs necessitate monitoring of serum concentration and adjustment of individual dosage regimen early in the course of treatment with aminoglycosides. |
| Key Words:
Gentamicin, Amikacin, Pharmacokinetics |
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