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Acute Tubular Necrosis Associated with typhoid Fever

Journal of the Korean Pediatric Society 1994;37(2):250-256.
Published online February 15, 1994.
Acute Tubular Necrosis Associated with typhoid Fever
Pill-Jin Shin1, Ho-Sung Lee1, Byoung-Soo Cho1, Chang-Il Ahn1, Mun-Ho Yang2
1Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea
2Department of Anatomical Pathology, College of Medicine, Kyung Hee University, Seoul, Korea
장티푸스에 의한 급성 세뇨관 괴사
신필진1, 이호성1, 조병수1, 안창일1, 양문호2
1경희대학교 의과대학 소아과학교실
2경희대학교 의과대학 해부병리과학교실
Abstract
Acute tubular necrosis has been rarely reported as a complication of typhoid fever in the literature. We experienced four cases of acute tubular necrosis associated with typhoid fever in children. Patients showed significant titer of widal reaction associated with acute renal failure and one of them rised in 2 months after onset of clinical symptoms. Renal biopsy findings were compatible with acute tubular necrosis and immune complexes were not deposited in the glomeruli. Clinical and urinary findings were normalized by hemodialysis and antibiotic therapies. In conclusion, close longterm follow up of widal titer is mandatory in acute tubular necrosis, especially when associated with high fever.
Key Words: Typhoid fever, Acute tubular necrosis, Renal biopsy


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