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Candida Esophagitis in Infancy-A Report of 3 Cases

Journal of the Korean Pediatric Society 1994;37(2):269-275.
Published online February 15, 1994.
Candida Esophagitis in Infancy-A Report of 3 Cases
Ho Sung Kim2, Youn Woo Kim2, Jae Geon Sim2, Beom Soo Park2, Hoan Jong Lee2, Joong Gon Kim2, Jeong Kee Seo2, Je Geun Chi1
1Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
2Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
내시경에 의해 확진된 영아 Candida 식도염 3례
김호성2, 김연우2, 심재건2, 박범수2, 이환종2, 김중곤2, 서정기2, 지제근1
1서울대학교 의과대학 병리학교실
2서울대학교 의과대학 소아과학교실
We experienced 3 cases of Candida esophagitis in infancy which were diagnosed by esophageal endoscopy, First case, 10 month-old boy with combined immune deficiency had suffered from oral thrush and poor feeding for more than 4 months. Esophageal endoscopy revealed multiple whitish creamy patches on the friable erythematous and necrotic mucosa of the esophagus, He was firstly treated with amphotericin-B but in vain, Then he was treated with fluconazole (5 mg/kg/day) and in a few days oral thrush nearly disappeared and endoscopy after 2 weeks revealed complete healing of oral thrush, poor feeding and intermittent fever. He was treated with fluconazole and oral thrush was imporved. He was discharged without follow up endoscopy. Third case, 4 month-old girl with liver the endoscopic examination of esophageal varix, First 2 cases showed multiple small filling defects and decreased motility on esophagography. Candida antigen was not detected in the sera of all 3 cases of candidiasis. We conclude that Candidia esophagitis should be suspected when an infant has been suffering from long-term treatmet-resistant oral thrush and poor feeding and that esophageal endoscopy can be easily performed in infants also and useful in diagnosing esophagitis and assessing the outcome of treatment.
Key Words: Candida esophagitis, Esophageal endoscopy, Fluconazole

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