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A Clinical Observation on Lupus Nephritis in Children

Journal of the Korean Pediatric Society 1994;37(6):842-849.
Published online June 15, 1994.
A Clinical Observation on Lupus Nephritis in Children
Kang Mo Ahn1, Jae Sung Ko1, Hye Won Park1, Il Soo Ha1, Hae Il Cheong1, Yong Choi1, Hee Joo Kim2
1Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
2Department of Pediatrics, Boramae Hospital, Seoul, Korea
소아에서 발생한 낭창성 신염 -임상양상 및 경과-
안강모1, 고재성1, 박혜원1, 하일수1, 정해일1, 최용1, 김희주2
1서울대학교 의과대학 소아과학교실
2보라매병원 소아과
We reviewed the clinical features, histrologic patterns and clinical courses of 30 children with lupus nephritis retrospectively, and the results were summerized as follows; 1) The male to female ratio was 1:2.8, and the mean age at the onset was 108/12 years. 2) The clinical symptoms were diverse, and malaise, weight loss, anorexia, fever and malar rash were the most frequent findings. 3) Among the immunologic tests, FANA and anti-ds-DNA test revealed the highest sensitivity with positive rates of 97% and 87%, respectively. 4) Clinically, 57% of patients had active nephrotic syndrome at the onset, and 33% showed asymptomatic urinary abnormalities. Histologically, diffuse proliferative lupus nephritis (Class IV) was the most common findings (70%) 5) During the follow-up period, one children with Class IV lupus nephritis expired. And 8 out of 9 cases with renal insufficiency at the onset showed improvement of renal function after treatment with corticosteroid and cytotoxic agents. In conclusion, the clinical features and histologic findings of lupus nephritis in children were diverse. Early diagnosis and proper treatment can prevent rapid deterioration of renal function and improve long-term survival rate.
Key Words: Lupus nephritis, Children

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