| A Comparative Study o fIntavenous Methylprednisolone Dosage for Treatment of Children with Acute Idiopathic Thrombocytopenic Purpura |
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Eun Ju Shin, Yeong Jae Song, Woo Yeong Chung, Tae Gyu Hwang, Soon Yong Lee |
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Department of Pediatrics, Inje University College of Medicine, Pusan Paik Hospital, Pusan, Korea |
| 급성 특발성 혈소판 감소성 자반증 환아에 있어서 Methylprednisolone 정주치료 용량에 따른 혈소판 증가에 관한 비교 연구 |
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신은주, 송영재, 정우영, 황태규, 이순용 |
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인제대학교 의과대학 부산백병원 소아과학교실 |
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| Abstract |
Purpose
: It is well known that use of intranenous methylprednisolone(IVMP)for the patients with idiopathic thrombocytopenic purpura(ITP) is not only as effective as use of intravenous gammaglobulin to mincrease platelets quickly, but also the former is less expensive than the latter. As the adequate dosage of IVMP has not been fully elucidated, we have tried to determine it.
Methods
: The subjects were 35 childhood patients below 15 years of age, who were diagnosed with ITP for the first time and whose platelet count was less than 20,000/mm3 at diagnosis. We divided them into three groups : Group A included 8 cases with IVMP dosage of 5mg/kg/day, Group B included 9 patients with IVMP dosage of 10mg/kg/day, and group C included 18 patients with IVMP dosage of 20mg/kg/day. We checked the platelet count every day after IVMP administration daily for 5 days and also observed for side effects if any.
Results
: After IVMP administration, we obseved increasing tendency of platelets in all three groups, of which group C was more rapid and higher in increasing platelets than the other groups(p<0.05). After IVMP therapy for 5 days, cases with platelets>20,000/mm3 were 6(75%) in group A, 7(78%) in group B, and 18(100%) in group C. Cases with platelets >50,000/mm3 were 5(63%), 6(67%), 17(94%) in groups A, B, C, respectively, and cases with platelets>100,000/mm3 were 3(38%), 5(56%), 14(78%), in group A, B, C, respectively. And there were no remarkable side effects except a case of transient hypertensive headache in group C.
Conclusion
: We concluded that the effectiveness of IVMP therapy for increasing platelets was more rapid and higher in group C than in group A or B, and side effect was minimal. |
| Key Words:
Idiopathic thrombocytopenic purpura, Methylprednisolone |
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