| Changes of Measles Specific IgG after Active Immunization of Measles in Korean Children |
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Young Kyoo Shin, Jae Kyun Yoon, Ji Tai Choung, Young Chang Tockgo |
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Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea |
| 홍역예방접종후 연령 증가에 따른 혈청내 홍역 특이 IgG의 변동 |
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신영규, 윤재균, 정지태, 독고영창 |
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고려대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: Despite preventive measures, measles outbreaks ocurred in 1989, 1990 and
1994 in Korea. Especially, the proportion of immunized school aged children and adolescents was increased, and the reason was, in our opinion, primary and secondary vaccine failure after measles immunization. In this context, we attempted to evaluate the changes of measles specific IgG levels in various age groups of immunized children.
Methods
: From Jun. 1. 1994 to Mar. 31. 1995, the sera were collected from immunized
children aged 1.5 to 12 years who had no history of natural measles. We
measured the measles specific IgG using enzyme linked immunosorbent assay (ELISA:
SIATM Measles IgG Kit, SIGMA Co. StLouis, Mo).
Results
: The seropositivity of immunized children aged 1.5 to 12 years was 86.1%
and 11 year old age group showed lowest level, 66.0%. As children were getting older,
the measles antibody level decreased significantly(r=-0.2264, p<0.001).
Conclusion
: Above results partially explain the reasons for recent measles occurrences in immunized children and suggest that it is necessary to modify the current immunization schedule of measles in Korea. |
| Key Words:
Measles, IgG, Children, Immunization |
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