| Antineutrophil Cytoplasmic Antibody in Kawasaki Disease |
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Soh-Yeon Kim1, So Young Kim1, Wonbae Lee1, Kyong Su Lee1, Ji-Min Kang2 |
1Department of P ediatrics, Catholic University Medical College, Seoul, Korea
2Department of Clinical Pathology, Catholic University Medical College, Seoul, Korea |
| 가와사끼병에서의 Antineutrophil Cytoplasmic Antibody의 의의 |
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김소연1, 김소영1, 이원배1, 이경수1, 강지민2 |
1가톨릭대학교 의과대학 소아과학교실
2가톨릭대학교 의과대학 임상병리학교실 |
Correspondence:
Wonbae Lee, Email: 1
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| Abstract |
Purpose
: Antineutrophil cytoplasmic antibody(ANCA) has been identified in various disorders
including Wegener' s granulomatosis, microscopic polyarteritis and Kawasaki disease. Measuring
this antibody has a diagnostic role. It facilitates monitoring disease activity and may also help
understand the pathogenesis of the diseases in which it is found. We investigated the correlation
between the hematologic findings and ANCA in acute Kawasaki disease and the diagnostic
potential of ANCA to predict coronary artery involvement.
Methods
: Thirty-eight patients who met the diagnostic criteria for Kawasaki disease were
enrolled in this study. We sampled and investigated the hematologic findings and the assay of
ANCA before intravenous immunoglobulin treatment and weekly echocardiographs weekly.
Results
: There was no sexual difference between ANCA positive and negative group. The age
in ANCA positive group was significantly lower than in ANCA negative group. Duration of fever
before treatment in ANCA positive group were not significantly different from those in ANCA
negative group. In ANCA positive group, the mean WBC count and the mean ESRs were higher
than in ANCA negative group. There was no relation between ANCA and coronary artery
involvement
Conclusion
: The assays of ANCA in acute Kawasaki disease does not help to predict disease
activity and coronary artery involvement. |
| Key Words:
Kawasaki disease, Antineutrophil cytoplasmic antibody |
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