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Antineutrophil Cytoplasmic Antibody in Kawasaki Disease

Journal of the Korean Pediatric Society 1998;41(6):808-812.
Published online June 15, 1998.
Antineutrophil Cytoplasmic Antibody in Kawasaki Disease
Soh-Yeon Kim1, So Young Kim1, Wonbae Lee1, Kyong Su Lee1, Ji-Min Kang2
1Department of P ediatrics, Catholic University Medical College, Seoul, Korea
2Department of Clinical Pathology, Catholic University Medical College, Seoul, Korea
가와사끼병에서의 Antineutrophil Cytoplasmic Antibody의 의의
김소연1, 김소영1, 이원배1, 이경수1, 강지민2
1가톨릭대학교 의과대학 소아과학교실
2가톨릭대학교 의과대학 임상병리학교실
Correspondence: 
Wonbae Lee, Email: 1
Abstract
Purpose
: Antineutrophil cytoplasmic antibody(ANCA) has been identified in various disorders including Wegener' s granulomatosis, microscopic polyarteritis and Kawasaki disease. Measuring this antibody has a diagnostic role. It facilitates monitoring disease activity and may also help understand the pathogenesis of the diseases in which it is found. We investigated the correlation between the hematologic findings and ANCA in acute Kawasaki disease and the diagnostic potential of ANCA to predict coronary artery involvement.
Methods
: Thirty-eight patients who met the diagnostic criteria for Kawasaki disease were enrolled in this study. We sampled and investigated the hematologic findings and the assay of ANCA before intravenous immunoglobulin treatment and weekly echocardiographs weekly.
Results
: There was no sexual difference between ANCA positive and negative group. The age in ANCA positive group was significantly lower than in ANCA negative group. Duration of fever before treatment in ANCA positive group were not significantly different from those in ANCA negative group. In ANCA positive group, the mean WBC count and the mean ESRs were higher than in ANCA negative group. There was no relation between ANCA and coronary artery involvement
Conclusion
: The assays of ANCA in acute Kawasaki disease does not help to predict disease activity and coronary artery involvement.
Key Words: Kawasaki disease, Antineutrophil cytoplasmic antibody


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