| The Changes of Production of RANTES and Gro-α in Kawasaki Disease |
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Young Hwan Lee1, Hyun Kyung Lee1, Bo Hyeong Lee1, Sun Yoon Jung1, Hee Sun Kim2, Sang Bum Lee3 |
1Department of Pediatrics, College of Medicine, Yeungnam University, Taegu, Korea
2Department of Microbiology, College of Medicine, Yeungnam,Taegu, Korea
3Department of Pediatrics, College of Medicine, Kyungpook National University†, Taegu, Korea |
| 가와사끼병에서의 RANTES와 Gro-α의 생성 변화 |
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이영환1, 이현경1, 이보형1, 정선윤1, 김희선2, 이상범3 |
1영남대학교 의과대학 소아과학교실
2영남대학교 의과대학 미생물학교실
3경북대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: Kawasaki disease is probably driven by abnormalities of the immune system after
infectious insult. In this report, a clinical review with laboratory parameters and the changes of
the plasma levels of chemokines(RANTES and Gro-α) was undertaken according to the clinical
stage of Kawasaki disease.
Methods
: This investigation included 74 samples from 21 patients(10 boys, 11 girls; mean age,
27.8 months) with Kawasaki disease who met the revised diagnostic guidelines and 5 samples
from healthy children. The plasma levels of RANTES and Gro-α were measured by enzymelinked
immuno-sorbent assay(ELISA). To analyze the pattern of the gene expression of chemokine
mRNA for lymphotactin(Ltn), RANTES, IP-10, MIP-1β, MIP-1α, MCP-1, IL-8 and I-309 in the
peripheral blood monocyte, ribonuclease protection assays(RPA) were performed in 3 patients
whose plasma levels of RANTES were very low and not significantly changed after intravenous
immunoglobulin(IVIG) treatment.
Results
: The production of RANTES and Gro-α were markedly elevated during the acute and
subacute phases of Kawasaki disease compared to those of the normal control. In addition, interestingly,
the changing patterns of plasma level of chemokines were not consistent(biphasic) after IVIG
treatment. According to the RPA, the expression of RANTES was the most prominent among 8
kinds of chemokines and elevated in all phases of Kawasaki disease. But, there was no ovious
relation between clinical characteristics of the disease including the coronary artery dilatation and
the level of RANTES.
Conclusion
: These finding suggested that RANTES and Gro-α may play an important role in
pathophysiology of the Kawasaki disease. Longer follow-up and more case studies will be needed to
clearly establish the significance of the changes of RANTES and Gro-α in the pathophysiology
of Kawasaki disease. |
| Key Words:
Kawasaki disease, Chemokines, RANTES, Gro-α |
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