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A Case of Systemic Castleman's Disease in a Child and Successful Treatment with Oral Prednisolone

Korean Journal of Pediatrics 2005;48(4):443-447.
Published online April 15, 2005.
A Case of Systemic Castleman's Disease in a Child and Successful Treatment with Oral Prednisolone
So Eun Koo1, Mee Jeong Lee2, Jeong Eun Kim2, Joo Ryung Huh3, Thad Ghim1
1Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea
2Department of Pediatrics, College of Medicine, Dankook University, Cheonan, Korea
3Department of Pathology, University of Ulsan College of Medicine, Seoul, Korea
Prednisolone 투여로 효과적으로 치료된 소아의 전신형 Castleman병 1례
구소은1, 이미정2, 김정은2, 허주령3, 김태형1
1울산대학교 의과대학 소아과학교실
2단국대학교 의과대학 소아과학교실
3울산대학교 의과대학 병리학교실
Correspondence: 
Mee Jeong Lee, Email: lmjped@yahoo.co.kr
Abstract
Castleman's disease is a rare non-neoplastic lymphoproliferative disorder of unknown etiology. It is divided into three histologic subtypes; hyaline-vascular(HV), plasma cell(PC) type and mixed type (HV-PC). It has two clinical expressions. The localized form, which presents as a slow growing mass, has a relatively benign clinical course. The multicentric form is multilocated and holds significant morbidity. The mainstay of treatment of the localized form is surgical resection. The multicentric form requires medical treatment comprising prednisolone and other immunosuppressor drugs. The disease in children seems to have a more favorable course than in adults. We report a 13-year- old boy with Castleman's disease of multicentric form who was successfully treated with prednisolone and intravenous immunoglobulin.
Key Words: Castleman's disease , Child , Prednisolone , Immunoglobulin


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