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The significance of vascular endothelial growth factor(VEGF) in children with asthma and pneumonia

Korean Journal of Pediatrics 2006;49(2):192-197.
Published online February 15, 2006.
The significance of vascular endothelial growth factor(VEGF) in children with asthma and pneumonia
Seong Hwan Choi, Jung Yeon Shim, Myung Hwan Yoo, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seou
소아 천식과 폐렴에서 혈청 vascular endothelial growth factor 농도의 의의
최창환, 심정연, 유명환, 김덕수, 심재원, 정혜림, 박문수
성균관대학교 의과대학 강북삼성병원 소아과
Jung Yeon Shim, Email: jyssim@hotmail.com
: Vascular endothelial growth factor(VEGF) is a key cytokine for controlling vascular permeability and angiogenesis, which is one of the major findings in airway remodeling. However, it is not well known if it is associated with acute lower respiratory tract disease such as lobar pneumonia. The aim of this study is to compare serum VEGF levels in patients with asthma according to its severity and duration of cough, and to compare its levels with children with lobar pneumonia.
: Using a sandwich enzyme-linked immunosorbent assay, the serum VEGF levels were measured in 16 mild asthmatics, 14 moderate to severe asthmatics, six children with lobar pneumonia, and 22 control subjects. The asthmatics were also classified into three groups according to the duration of cough. Serum VEGF levels were compared in each group.
: Serum VEGF levels were significantly increased in the children with moderate to severe asthma and lobar pneumonia compared to the children with mild asthma and control subjects. Serum VEGF levels were higher in children with chronic coughs of more than two weeks than in children with coughs lasting less than two weeks. Serum levels of VEGF showed positive correlations with blood platelet and white blood cell counts.
: VEGF increased according to the severity of asthma and duration of cough in children with asthma. It may play an important role not only in chronic airway inflammation, but also in the acute inflammation in children with lower respiratory tract disease.
Key Words: Asthma , VEGF , Pneumonia , Cough , Airway inflammation

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