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Clinical study in children with cerebral palsy associated with or without epilepsy

Korean Journal of Pediatrics 2006;49(5):529-532.
Published online May 15, 2006.
Clinical study in children with cerebral palsy associated with or without epilepsy
Yongjoo Ahn1, Hyejeon Chung1, Suk Youn1, Euihyun Cho2, Sajun Chung1
1Department of Pediatrics, College of Medicine, Kyunghee University Hospital, Seoul
2Chungju Medical Center, Korea
뇌성마비아의 간질 발생에 대한 임상연구
안용주1, 정혜전1, 윤석1, 조의현2, 정사준1
1경희대학교 의과대학 소아과학교실
2청주의료원 소아과
Sajun Chung, Email: sajchung@khmc.or.kr
: To study the spectrum of epilepsy in children with cerebral palsy.
: A total of 93 consecutive patients with cerebral palsy(CP) were retrospectively suited. Criteria for inclusion were a follow-up period of at least 2 years. The study examined the correlation between the incidence of epilepsy and seizure types in the different forms of CP. Other factors associated with epilepsy, such as age of first seizure, occurrence of abnormalities on brain imaging, and electroencephalogram were also analyzed.
: The overall prevalence of epilepsy in children with CP was 46.2 percent. The incidence of epilepsy was predominant in patients with mixed, diplegic, and quadriplegic palsies : 55.5 percent, 51.6 percent, and 50.0 percent in frequency. The first seizure occurred during the first year of life in 48.8 percent of patients with epilepsy. Generalized tonic-clonic seizures were the most common seizure type(44.2 percent), predominant in diplegic patients(64.3 percent). On the other hand, infantile spasms and myoclonic seizures were the main cause of seizures among quadriplegic children(60 percent and 40 percent, respectively). The occurrence of epilepsy was more popular in the group with abnormal brain imagings; especially encephalomalacia and cortical atrophy. All children with epilepsy in this study showed abnormal electroencephalogram(EEG) findings: Generalized abnormalities were observed in 55.8 percent of children with epilepsy; more dominantly in quadriplegic children(80.0 percent); and 40 percent of children with diplegia showed focal abnormalities.
: Cerebral palsy is associated with a higher incidence of seizure disorders, which, in the majority, has its onset in the first year of life; brain imaging and EEG are most effective in spotting epilepsy in children with CP.
Key Words: Epilepsy , Cerebral palsy

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