| Clinical characteristics of vitamin D deficiency rickets in infants and preschool children |
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Kyoung Huh, Mi Kyeong Woo, Jung Rim Yoon, Gyu Hong Shin, Myoung Jae Chey, Mi Jung Park |
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Department of Pediatrics, Inje University College of Medicine, Seoul, South Korea |
| 비타민 D 결핍성 구루병 영ㆍ유아의 임상적 특징 |
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허경, 우미경, 윤정림, 심규홍, 최명재, 박미정 |
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인제대학교 의과대학 상계백병원 소아청소년과 |
Correspondence:
Mi Jung Park, Tel: +82.2-950-1075, Fax: +82.2-951-1246, Email: PMJ@paik.ac.kr
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| Abstract |
Purpose
: Vitamin D deficiency rickets is a significant public health problem that results from insufficient exposure to sunlight and inadequate vitamin D supplementation. The purpose of this study is to identify the clinical characteristics of vitamin D deficiency rickets in infants.
Methods
: Data of 35 infants diagnosed as vitamin D deficiency rickets at Sanggye-Paik Hospital, Seoul, Korea, from March 2007 to May 2009 were reviewed. Children with plasma 25-hydroxyvitamin D levels<15 ng/mL and 15-30 ng/mL were considered to have vitamin D deficiency and vitamin D insufficiency, respectively.
Results
: Thirty-five infants (22 boys, 13 girls) were diagnosed with rickets. Mean age at diagnosis was 7.4¡¾7.1 months (range: 0.1-29.8 months). Eighteen infants (51%) were vitamin D deficient and seventeen infants (49%) were insufficient. Twenty-eight of all (80%) diagnosed as subclinical rickets. Twenty-nine infants (83%) were below the age of 12months. Twenty infants (57%) had breastfed and ten infants (29%) had iron deficiency anemia. Nine of breastfed infants (45%) were vitamin D deficient and ten of their mothers were vitamin D insufficient. Overall, radiographic evidence of rickets was present in 93% of the cases. Radiographic sign of rickets was evident even in vitamin D insufficient state.
Conclusion
: It is important for the clinician to screen for subclinical vitamin D deficiency rickets in inadequately supplemented infants by pairing 25-hydroxyvitamin D levels with wrist radiographs. A nationwide epidemiological study of vitamin D deficiency rickets must be conducted and evidence-based national guidelines must be defined to prevent rickets. |
| Key Words:
Vitamin D deficiency, Rickets, Infant |
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