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A case of idiopathic precocious puberty treated with a luteinizing hormone relaeasing hormone analog.

Journal of the Korean Pediatric Society 1991;34(8):1132-1138.
Published online August 31, 1991.
A case of idiopathic precocious puberty treated with a luteinizing hormone relaeasing hormone analog.
Keun Hee Chung, Yoo Mi Kim, Mi Won Kim, Soon Ki Kim, Moon Soo Park, Jin Keun Chang
Department of Pediatrics, Han II Hospital, Seoul, Korea
특발성 진성 성조숙증에 있어서 황체형성호르몬 유리호르몬 유사물질에 의한 치험 1례
정근희, 김유미, 김미원, 김순기, 박문수, 장진근
한일병원 소아과
Received: 16 August 1990   • Accepted: 24 October 1990
Abstract
We experienced a 4 year girl with idiopathic precocious puberty treated with a long acting LHRH analog (Buserelin). As an indction therapy she received LHRH analog for 6 months in subcutaneous route. After then she was maintained by intranasal therapy for 6 months. One month after the induction therapy began, we observed prepunbertal pattern of LHRH stimulation test and significant suppression of 17B-estradiol level. These hormonal responses were maintained after switching to intranasal therapy except slightly increased 17B-Estradiol. We also observed significant deceleration of growth velocity and bone maturation rate as well as clinical and behavioral improvement. During 1 year period of the efficacy and safety of LHRH analog by intranasal and subcutaneous routes in patients with sexual precocity. So we report this case with a brief review of the literatures.
Key Words: Idiopathic precocious puberty, LHRH analog


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