| The Effect of Oral Vitamin E on Hemolytic Anemia of the Premature Infants. |
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Hwa Kyoung Oh, Kwang Sik Yoo, Yong Sil Chi, Myung Jin Kim, Mi Na Lee |
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Department of Pediatrics, Cheil General Hospital, Seoul, Korea |
| 비타민 E 투여가 미숙아 용혈성 빈혈에 미치는 영향 |
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오화경, 유광식, 지용실, 김명진, 이미나 |
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제일병원 소아과 |
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Received: 18 April 1989 • Accepted: 29 June 1989 |
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| Abstract |
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The study was designed to evaluate the effect of vitamin E on hemolytic anemia of premature
infants. Sixty infants delivered in Cheil Hospital from March 1987 to December 1988 with birth weight
below 2500 gm or gestational age below 37 weeks were studied. Thirty infants received oral vitamin
E 25 IU/day until their birth weight doubled. Thirty infants served as control.
The results were as follower:
1) No significant difference was present in birth weight or gestational age between study and
control group.
2) No significant correlation was found between gestational age, birth weight and plasma vitamin
E levels.
3) The plasma level of vitamin E significantly increased 1 week after administration of vitamin E.
4) Infants who received vitamin E demonstrated a significant increase in hemoglobin level (9.2 ±0.
13 gm%) compared to the control (7.8±0.52 gm%) at 10 wks of life.
5) Infants of both groups showed significant difference in reticulocyte count, 1.72±0.09% in vitamin
E group and 2.97 ±1.25% in the control group.
In premature infants the routine administration of vitamin E is recommended to prevent hemolytic
anemia developing ant 6 to 10 wks after birth. |
| Key Words:
Vitamin E, Hemolytic anemia |
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