| A Case of Doxorubicin-induced Dilated Cardiomyopathy. |
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Sang Young Jeong, Soo Chun Kim, Sung Ho Cha, Young Mook Choi, Chang Il Ahn |
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Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea |
| Doxorubicin 에 의한 확장성 심근증 1례 |
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정상영, 김수천, 차성호, 최용묵, 안창일 |
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경희대학교 의과대학 소아과학교실 |
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Received: 4 October 1988 • Accepted: 21 December 1988 |
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| Abstract |
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Doxorubicin is one of the most effective chemotherapeutic agents in the treatment of leukemia,
lymphoma and various solid tumors. Because of dose-dependent degenerative cardiomyopathy,
however, doxorubicin theraphy may be discontinued ineffectively early. Doxorubicin-induced conges-
tive heart failure carries a very poor prognosis since it is lethal in 60% of patients. Various methods
for evaluating the cardiotoxic effect have been employed such as EKG, systolic time interval,
echocardiography, radionuclide angiography and endomyocardial biopsy.
We have experienced a case of doxorubicin-induced cardiomyopathy with finding of increased
internal diameter of left ventricle and decreased left ventricular function (increased systolic time
interval) in echocardiogram and increased CT ratio (63%) in chest X-ray in a girl who had symptoms
and signs of congestive heart failure, then she has treated with anticancer chemotherapeutic agents
containing doxorubicin (total cumulative dose is 400 mg) due to retinoblastoma.
The case was presented with brief review of literature. |
| Key Words:
Doxorubicin, Cardiomyopathy |
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