| Clinical Study of Hypophosphatemic Rickets. |
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Seok Min Choi1, Duk Hi Kim1, Chin Suck Suh2 |
1Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
2Department of Radiology, College of Medicine, Yonsei University, Seoul, Korea |
| 저인산성 구루병에 관한 임상적 고찰 |
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최석민1, 김덕희1, 서진석2 |
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 방사선과학교실 |
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Received: 10 March 1989 • Accepted: 10 March 1989 |
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| Abstract |
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Hypophosphatemic rickets is a disorder characterized by a normal or slightly reduced serum
calcium level, a moderately reduced serum phosphorus level and elevated alkaline phosphatase
activity. The usual mode of inheritance is X-linked dominant and postulated mechanism is a selective
disorder of tubular reabsorption of phosphate, defective conversion of 21-hydroxyvitamin D3 to
calcitriol and increased catabolism of calcitriol.
In children with renal hypophosphatemic rickets, growth failure is the clinical feature of major
concern and the diagnosis is usually made only after significant growth retardation and bone
deformity are evident.
The combined administration of calcitriol and phosphate is currently the best and the most
accepted treatment for renal hypophosphatemic rickets.
We experienced 8 cases of hypophosphatemic rickets and report with a brief review of literatures. |
| Key Words:
Hypophosphatemic Rickets |
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