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Plasma Renin Activity (PRA) in Peripheral Vein and Renal Veins in Normotensive Children with Cyanotic Congenital Heart Disease.

Journal of the Korean Pediatric Society 1988;31(8):1021-1027.
Published online August 31, 1988.
Plasma Renin Activity (PRA) in Peripheral Vein and Renal Veins in Normotensive Children with Cyanotic Congenital Heart Disease.
Sang Kyu Park, Hae Il Cheong, Chung Il Noh, Yong Soo Yun, Yong Choi, Kwang Wook Ko
Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
정상혈압을 가진 청색증 선천성 심질환 소아에서 말초정맥 및 신정맥의 혈장 Renin 활성도
박상규, 정해일, 노정일, 윤용수, 최용, 고광욱
서울대학교 의과대학 소아과학교실
Received: 15 December 1987   • Accepted: 16 March 1988
Abstract
PRA’s in peripheral vein, both renal veins, and inferior vena cava (IVC) were measured in 25 normotensive children without renal disease undergoing cardiac catheterization for their underlying cyanotic congenital heart disease. And we presented the results as reference values/ranges of PRA in children. 1) There was no significant difference in PRA between both side renal veins at any absolute PRA levels with a mean ratio (RT/LT) of 0.97±0.22. 2) The mean PRA ratio of one renal vein with higher PRA level to the contralateral renal vein with lower PRA level (R/RC) was 1.19, and the 95% confidence limit was 1.0 to 1.59. And 3 children(12%) showed a ratio higher than 1.5 with a highest value of 1.68. 3) The increase in hematocrit correlated linearly with the increase in peripheral vein PRA, with a coefficient of correlation of 0.67 (p< 0.005). In conclusion, a more prudent judgment for the meaning of measured PRA’s should be needed in children with severe polycythemia.
Key Words: Plasma Renin Activity, Hematocrit, Blood Viscosity, Cyanotic Congenital Heart Disease.


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