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A Clinicopathologic Study on Postinfectious Glomerulonephritis.

Journal of the Korean Pediatric Society 1988;31(6):723-730.
Published online June 30, 1988.
A Clinicopathologic Study on Postinfectious Glomerulonephritis.
Hong Jin Lee, Kwang Wook Ko
Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
감염후 사구체신염에 대한 임상 및 병리학적 고찰
이홍진, 고광욱
서울대학교 의과대학 소아과학교실
Received: 9 November 1987   • Accepted: 9 November 1987
Abstract
38 biopsy proven postinfectious glomerulonephritis patients were analyzed retrospectively in view of clinicopathological correlation. 1) Of the 38 patient reviewed, 23 cases were male and 15 female and the male to female ratio was 1.5:1. The mean age of onset was 9.8±3.2 years old with 2 peaks at 7 and 12 years of age. 2) The clinical presentations on admission were acute nephritic syndrome (15 cases, 39%), acute nephritic syndrome associated with nephrotic syndrome (12 cases, 32%), nephrotic syndrome (3 cases, 8%), recurrent gross hematuria (4 cases, 10.5%) and acute renal failure (4 cases, 10.5%). The mean of selectivity index of proteinuria was 0.43 ±0.5. 3) On immunofluorescent microscopy, C3 was deposited on all cases examined, IgG on 56%, IgM on 38% and IgA on 16%. IgG was deposited mainly on peripheral capillary wall and IgA was deposited with other immnoglobulins or Ca on small amount. 4) On electron microscopy, electron dense deposits or humps were found subepithelially, subendoth- elially, intramembrandusly, mesangially or in combination. Most frequent site of deposit was sube- pithelial portion. 5) Abnormality on urinalysis or serological abnormality were all normalized within 2 year 2 month and no patient have progressed to chronic renal failure. 6) Proteinuria was severe and longstanding on patients with severe cellular proliferation or mainly peripheral depositions of immunoglobulin or complement.
Key Words: Clinicopathologic


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