| Clinical, Hematological and Cytogenetical Studies of Leukemia in Children. |
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Young Wook Kim, Chan Gyu Hwang, Ki Bok Kim |
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Department of Pediatrics, Kwangju Christian Hospital |
| 소아기 백혈병의 임상 혈액학 및 세포유전학적 고찰 |
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김용욱, 황찬규, 김기복 |
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광주기독병원 소아과 |
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| Abstract |
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A review was made on the clinical, hematological and cytogenetical findings of 68 children
diagnosed as leukemia at Pediatric Department, Kwangju Christian Hospital, during a period of 10
years from Jan. 1975 to Dec. 1985.
The results were as follows:
1) The sex ratio of 68 children diagnosed as Leukemia was 1:1. The most common age group was
11-12 year(19.1%), followed by the group of 3-4 year(16.2%).
2) Of the 68 cases of leukemia, 47 cases(69.1%) were found to be Acute Lymphocytic Leukemia, 19
cases(28%) were diagnosed Acute Myelocytic Leukemia and 2 cases were diagnosed as Chronic
Myelocytic Leukemia.
3) The durations of clinical manifestation before the diagnosis were less than 1 month in 67.7%, 2
to 5 months on 23.5%, and more than 6 months in 8.8%.
4) The subjective symptoms on admission were in the order of frequency: pallor(86.8%), fever(54.4%), fatigue(38.2%), bleeding(27.9%) and abdominal pain(26.5%). Common objective signs were
lymphadenopathy(54.4%), splenomegaly(44.1 %), hepatomegaly(36.8%) and purpura(19.1%).
5) The examination of peripheral blood revealed leukocyte counts of 20,000 to 50,000/mm3 in 29.4
% of all cases, over 50,000/mm3 in 23.5%, under 5,000/mm3 in 19.1%, 5,000 to 10,000/mm3 in 14.7%
and 10,000 to 20,000/mm3 in 13.3%. Hemoglobin levels were 4.0 to 8.0 g/dl in 61.7%, under 4.0 g/dl in 23.5% and over 8.0 g/dl in 14.8%. Platelet count under 50,000/mm3 was found in 48.6%, over 100,000/mm3
in 26.4% and 50,000 to 100,000/mm3 in 25%. Reticulocytes under 2% was in 60.3%, 2 to 4% and in 30.9%
and over 4% was in 8.8%.
6) Cultures of peripheral blood and/or bone marrow for chromosomal analysis were performed in
45 cases, among which karyotype patterns were obtained in 18 cases and chromosomal abnormalities
were found in 10 cases. Abnormal karyotype patterns found were as follows: 2 cases of Down
syndrome associated with ALL, 4 cases of A-group abnormalities, 3 cases of G-group abnormalities
and 1 case of Tetraploid(92,XY).
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| Key Words:
Leukemia in children, Chromosomal analysis.
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