| Hyperlipidemia and Hyperlipoproteinemia in Focal Segmental Glomerulosclerosis Nephrotic Syndrome. |
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Heui Jeen Kim, Kwang Wook Ko |
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Department of Pediatrics, College of Medicine, Seoul National University |
| Focal Segmental Glomerulosclerosis 賢症候群에서의 血淸脂質과 高脂質番白血症 |
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金照珍, 高光皇 |
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서울大學校 醫科大學 小兒科學敎室 |
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| Abstract |
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Sera obtained from 23 hospitalized patients with focal segmental glomerulosclerosis nephrotic
syndrome which is confirmed by kidney biopsy, were analyzed for serum albumin, serum
lipids, 24hr urine protein, creatinine clearance, HDL-cholesterol. In 19 of the patients
lipoproteins were analyzed. the following results were obtained.
1) Serum phospholipid (PL) was increased whenever serum total cholesterol (TC) was
increased but to a lesser degree. The ratio of TC/PL were greater than normal (Fig. 1).
The relationship between TC and TG (triglyceride) was very irregular (Fig. 2).
2) Concentrations of serum cholesterol was related inversely to serum abumin levels (r=— 0.57, Fig. 3).
The relationship between triglyceride and albumin was less regular than that of cholesterol(r= — 0.43, Fig. 5).
3) No significant correlation between serum lipids and the 24hr urine protein excretion or creatinine clearance was noted. 4) Serum lipoprotein patterns were determined in 19 patients. Fifteen of the 19 nephrotic patients had abnormal lipoprotein patterns. Half of the hyperlipoproteinemias were Fredrickson,type lb (Table 4).
5) HDL-cholesterol ievels were increased in 4 patients and decreased in 5 patients.
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| Key Words:
Focal segmental glomerulosclerosis nephrotic syndrome, hyperlipidemia,
hyperlipoproteinemia.
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