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Lipoprotein Profiles in Minimal Change Nephrotic Syndrome.

Journal of the Korean Pediatric Society 1983;26(3):237-246.
Published online March 31, 1983.
Lipoprotein Profiles in Minimal Change Nephrotic Syndrome.
Yong Choi, Heui Jeen Kim, Hae Il Cheong, Jeong Kee Seo, Kwang Wook Ko
Department of Pediatrics, college of medicine, Seoul, National University,Korea.
Minimal Lesion 腎症候詳에 있어서의 血淸脂質憂白의 性狀
최 용, 김희진, 정해일, 서정기, 고광욱
서울대학교 의과대학 소아과학교실
Data obtained from 59 hospitalized patients with minimal change nephrotic syndrome which was confirmed by kidney biopsy, were analyzed for serum albumin, serum lipids, 24hr urine protein, creatinine clearanee, HDL-eholesterol. In 38 of the patients, lipoproteins were analyzed. The following results were obained 1. Serum phospolipid (PL) was increased whenever serum total cholesterol (TC) was increased but to a lesser degree. The ratio of TC/PL were greater than normal (Fig. 1). The relationship between TC and TG (triglyceride) was very irregular (Fig. 2). 2. Concentrations of serum cholesterol and phospholipid were related inversely to serum albumin levels (r= — 0.62, r = — 0.66 respectively, Fig. 3 and 4). The relationship between triglyceride and albumin was less regular than that of the other lipids (Fig. 5). 3. No significant correlation between serum lipids and the 24hr urine protein excretion or creatinine clearance was noted (Fig. 6). 4. Serum lipoprotein patterns were determined in 38 patients. Thirty-one of the 38 patients had abnormal lipoprotein patterns. Fifty two percents of the hyperlipoproteinemias were Fredrickson type Hb (table 2). 5. HDL-cholesterol levels were not lower than that of the normal. 6. Cardiac symptoms or abnormal EKG findings were not detected. From the above findings, we can conclude that the risk of ischemic heart disease is not high in minimal change nephrotic syndrome in children.
Key Words: Minimal change nephrotic syndrome, Hyperlipoproteinemia, HDL-cholesterol.

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