| Clinical and Immunologic Studies on Epidemic Encephalitis. |
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Cheul Woo Park, Kwang Rhun Koo, Song Soo Moon, Ho Seung Yoo, Chang Soo Ra |
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Department of Pediatrics，College of Medicine, Chosun University Kuang ju，Korea |
| 유행성뇌염의 임상적 및 면역학적 고찰 |
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박철원, 구광련, 문송수, 유호성, 나창수 |
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조선대학교 의과대학 소아과학교실 |
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| Abstract |
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Epidemic encephalitis in the Korea is caused by arbovirus (Japanese encephalitis virts). And
this acute illness occurs annually during the late summer and early autumn months and is
more prevalent among children under 15 years with high mortality. 130 cases of epidemic encephalitis were hospitalized at the Department of Pediatrics, Chosun University Hospital, during the period of August-October, 1982. Authors investigated hemaggulutination inhibition (HI) antibody titer, serum immunoglobulin levels and the effects . . of dexamethasone on serum electlrolyte levels of the patients with epidemic encephalitis.
The results were as follows
1) The age was distributed between 2〜 16 years and male to female ratio was 2.1 : 1.
2) The common presenting symptoms on admission were high fever(96.9%), headache (70.0%),
disturbance of consciousness(68.5%), vomiting(66.2%) and generalized convulsion <41.5%).
3) HI antibody titers; among 130 cases of epidemic encephalitis, 34 cases(26%) showed
significant rise of HI antibody titer (1 : ^160) in a single acute serum which was obtained
within 7 days after the onset. And in the measurement of HI antibody titer using paired sera
of the patients with epidemic encephalitis(18 cases), all cases showed fourfold or more rise
in titers within or at 2 weeks after the first serum collection.
4) Serum immunoglobulin levels; IgG, IgA and IgM levels of 51 cases of proved epidemic
encephalitis were 1,562±325 mg/dl, 219±73 mg/dl and 220±62 mg/dl respectively, and these
levels were markedly elevated in compaired with those levels of the control group (p<〔0.01).
5) The effects of dexamethasone on serum electrolyte levels (Na, Cl and K) were studied
in 11 cases of epidemic encephalitis: serum electrolyte levels were remained within normal
ranges before and after dexamethasone therapy (0.5 mg and 1.0 mg/kg of bo(?y weight/day
in three devided doses every 8 hours) during the first three days after the admission, and no
differences observed between two groups.
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| Key Words:
Epidemic encephalitis, HI antibody, immunoglobulin, dexamethasone. |
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