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Original Article
Effect of Perinatal Asphyxia and Gentamicin on Urinary β2-microglobulin Concentration and Renal Function in Fullterm Neonates
Hoo Jae Hann, Seung Joo Lee
Clin Exp Pediatr. 1994;37(7):976-985.   Published online July 15, 1994
Perinatal asphyxia can cause ischemic injury to immature kidney of neonates. Proximal renal tubule is the most sensitive area, showing various manifestations ranging from mild reversible injury to irreversible tubular necrosis. Aminoglycosides can be nephrotoxic in therapeutic range in immature or damaged kidney. These are the very important factors to be taken into corsideration on fluid therapy and nephrotoxic drugs...
Pharmacokinetics of Gentamicin and Amikacin in Korean Children with Normal Renal Function
Jin Young Park, Ktung Bae Kwon, Mee Ran Kim, Hoan Jong Lee, Jin Q Kim, Wan Gyoon Shim, Kyoung Ho Park, Hae Lim Chung
Clin Exp Pediatr. 1994;37(2):185-192.   Published online February 15, 1994
We analysed retrospectively pharmacokinetic parameters of gentamicin and amikacin in 44 and 58 Korean pediatric patients, respectively, with normal renal function. Pharmacokinetic parameters were calculated from two concentrations in serum by method of Sawchuck. There was wide individual variation in peak serum concentrations of gentamicin and amikacin. Administration of the usually recommended doses yielded subtherapeutic concentration in 47% and 82%,...
Early detection of gentamicin nephrotoxicity using urinary beta2-microglobulin in neonates.
Mi Kyung Kim, Seung Joo Lee
Clin Exp Pediatr. 1991;34(7):940-948.   Published online July 31, 1991
Gentamicin, commonly used antibiotics in neonatal care, has a nephrotoxicity, but it is difficulto to assess renal function in early stage. This study evaluated the renal function and urinary β2-microglobulin excretion in 17 gentamicin treated and 11 control neonates. The results are as follows. 1) Urinary 02-M in gentamicin treated neonates were 0.84±0.17mg/L at postnatal day 1 and increased to 5.99±1.15mg/L at day 4, 14.17±2.39mg/L at day...