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Original Article
Sensitization of TNFα and Agonistic FAS/CD95 Antibody-Induced Apoptosis by INFγ on Neuroblastoma Cells
Ho Il Bang, Jong Duck Kim, Du Young Choi
Clin Exp Pediatr. 2003;46(7):702-709.   Published online July 15, 2003
Purpose : IFNγ sentitizes many tumor cells to TNFα and FASL-mediated apoptosis by enhancing the expression of TNF or FAS/CD95 receptor and modulating the activation of caspase and Bcl-2 family. It has been reported that IFNγ and TNFα synergistically caused differentiation and growth inhibition of neuroblastoma cells. Even though some neuroblastoma cell express FASR/FASL on the cell surface, they could...
Apoptotic Pathway Induced by Dominant Negative ATM Gene in CT-26 Colon Cancer Cells
Jung Chang Lee, Ho Keun Yi, Sun Young Kim, Dae Yeol Lee, Pyoung Han Hwang, Jin Woo Park
Clin Exp Pediatr. 2003;46(7):679-686.   Published online July 15, 2003
Purpose : Ataxia telangiectasia mutated(ATM) is involved in DNA damage responses at different cell cycle checkpoints, and signalling pathways associated with regulation of apoptosis in response to ionizing radiation(IR). However, the signaling pathway that underlies IR-induced apoptosis in ATM cells has remained unknown. The purpose of this study was, therefore, to investigate the apoptotic pathway that underlies IR-induced apoptosis in...
Leukoencephalopathy after CNS Prophylactic Therapy in Pediatric Hematologic Malignancy
Jun Hwa Lee, Sun Min Lee, Eun Jin Choi, Kun Soo Lee
Clin Exp Pediatr. 2003;46(6):566-571.   Published online June 15, 2003
Purpose : Leukoencephalopathy(LE) is one of the most serious complications in children with hematologic malignancies during the course of treatment. Early recognition is important to reduce the impact and sequelae from LE. We therefore investigated the clinical features of LE following central nervous system(CNS) prophylaxis in children with hematologic malignancies and evaluated the significance of regular check-ups of brain MRI. Methods...
Complications and Perinatal Factors According to the Birth Weight Groups in the Infants of Diabetic Mothers
Kyung-Ran Son, Hee-Jo Back, Chang-Yee Cho, Young-Youn Choi, Tae-Bok Song, Chun-Hak Park
Clin Exp Pediatr. 2003;46(5):447-453.   Published online May 15, 2003
Purpose : This study was performed to compare complications and perinatal factors according to the birth weight groups in the infants of diabetic mothers(IDM). Methods : Three hundred and one singleton diabetic mothers and their babies of more than 30 weeks' gestational age admitted in the department of Pediatrics, Chonnam University Hospital from January 1996 to March 2002 were enrolled....
Case Report
Thrombolytic Therapy and Long Term Follow-up Study in a Child with Kawasaki Disease Complicated by Giant Coronary Aneurysm with Thrombosis
Su Jung Moon, Su Ya Lee, Kyong Hee Na, Sun Young Park, Eun Young Kim, Kyoung Sim Kim, Yong Wook Kim
Clin Exp Pediatr. 2003;46(3):302-307.   Published online March 15, 2003
The long-term clinical issues in Kawasaki disease are concerned with the coronary artery lesions that result in aneurysmal formation, thrombotic occlusion, progression to ischemic heart disease, and premature atherosclerosis. We here report a 3 month old infant with Kawasaki disease complicated by giant coronary aneurysm with thrombosis. After urokinase(10,000 IU/kg) and heparin(400 IU/kg) were injected for two days as thrombolytic...
Original Article
Influence of Prognostic Factors on Survival Rate of Medulloblastoma Patient with Chemotherapy
Kyung Mi Shin, Sung Yeon Choi, Sung Chul Won, Chang Hyun Yang, Chuhl Joo Lyu, Chang Ok Suh, Joong Uhn Choi, Byung Soo Kim
Clin Exp Pediatr. 2003;46(2):178-182.   Published online February 15, 2003
Purpose : Brain tumors are the second most common tumor in childhood, and medulloblastomas comprise 15-25% of brain tumors. The well known prognostic factors are age at diagnosis, stage of disease, and extent of surgical excision. In this study, we analysed the prognostic factors in patients who received chemotherapy after excision. Methods : We reviewed the medical records of 61...
A Follow-Up Study after Discontinuation of Antiepileptic Drug Therapy in Children with Well-Controlled Epilepsy : The Factors that Influence Recurrence
Sa Jun Chung, Hye Jeon Chung, Young Mi Choi, Eu Hyun Cho
Clin Exp Pediatr. 2002;45(12):1559-1570.   Published online December 15, 2002
Purpose : There has been no exact answer to the question of when to discontinue antiepileptic drugs(AEDs) in children with well-controlled epilepsy for a long period. This study is about the risk factors of relapse after withdrawal of AEDs in seizure(Sz)-free patients to show a guideline for discontinuation of AEDs. Methods : One hundred and sixty-nine children were diagnosed as epileptic...
The Usefulness of MRCP in the Evaluation of Pancreaticobiliary Diseases in Children
Ji Hyun Uhm, Seung Yeon Lee, Ki Sup Chung
Clin Exp Pediatr. 2002;45(11):1381-1388.   Published online November 15, 2002
Purpose : Magnetic resonance cholangiopancreatography(MRCP) is a noninvasive method for imaging the pancreaticobiliary tree. The aim of this study was to evalute the usefulness of MRCP for the diagnosis of pancreaticobiliary diseases in children. Methods : From October 1996 to May 2001, 67 patients with obstructive jaundice and three patients with chronic recurrent pancreatitis were evaluated with abdominal ultrasonography and...
A Comparative Study of Parental Stress in Families with Epileptic Children
Bo-Young Kim, Sung Min Cho
Clin Exp Pediatr. 2002;45(10):1251-1262.   Published online October 15, 2002
Purpose : The purpose of this study is to assess and compare the stress of mothers and fathers in families with epileptic children, and to assess contributing factors to their stress. Methods : We used a family stress survey with 35 questionnaires to obtain data concerning the parents' perceived stress. Data were analyzed with SPSS 8.0 program using Pearson correlation coefficient, oneway ANOVA, and...
Case Report
A Case of Klinefelter Syndrome associated with Unilateral Multicystic Dysplastic Kidney in a Newborn Infant
Kyung A Ha, Sun Mi Chung, Eun Jin Choi, Jin Kyung Kim, Un Seok Nho, Jae Shin Park, Woo Taek Kim, Young Dae Kwon
Clin Exp Pediatr. 2002;45(9):1141-1145.   Published online September 15, 2002
Klinefelter syndrome is the most common chromosomal abnormality, with a 47, XXY karyotype and typical clinical findings of infertility, hypogonadism, reduced body hair, gynecomastia, tall stature, and incresed gonadotropins and decreased testosterone levels. In addition to this classic description, several other diseases have been discribed in Klinefelter syndrome such as unilateral renal aplasia, autoimmune disease, diabetes mellitus, sexual precoxity, renal...
Original Article
Clinical Characteristics and Genetic Analysis of Prader-Willi Syndrome
Ji Eun Lee, Kwang Bin Moon, Jong Hee Hwang, Eun Kyung Kwon, Sun Hee Kim, Jong Won Kim, Dong Kyu Jin
Clin Exp Pediatr. 2002;45(9):1126-1133.   Published online September 15, 2002
Purpose : Prader-Willi syndrome(PWS) is a complex disorder affecting multisystems with characteristic clinical features. Its genetic basis is an expression defect in the paternally derived chromosome 15q11-q13. We analyzed the clinical features and genetic basis of PWS patients for early detection and treatment. Methods : We retrospectively studied 24 patients with PWS in Department of Pediatrics, Samsung Medical Center, from...
Flexible Bronchoscopic Findings and Therapeutic Effects in Atelectasis of Children
Mee Yong Shin, Jong Hee Hwang, Eun Hee Chung, Jeong Hee Moon, Ju Suk Lee, Yong Min Park, Kang Mo Ahn, Sang Il Lee
Clin Exp Pediatr. 2002;45(9):1090-1096.   Published online September 15, 2002
Purpose : We evaluated the clinical manifestations, bronchoscopic findings and therapeutic effects of flexible fiberoptic bronchoscopy in atelectasis of children. Methods : Sixty six children who received bronchoscopy due to persistent atelectasis, acute severe atelectasis and incidental atelectasis on plain chest radiography were studied retrospectively. Results : The most common causative underlying disease was pneumonia(60.4%). Other underlying conditions were pulmonary tuberculosis, chronic...
Case Report
A Case of in-utero Vesicoamniotic Shunting and Postnatal Vesicostomy in Very Low Birth Weight Baby with Posterior Urethral Valve Syndrome
Sung-Hye Kim, Jae-Won Shim, Yun-Shil Chang, Soon-Ha Yang, Kwan-Hyeun Park, Dong-Kyu Jin, Won-Soon Park
Clin Exp Pediatr. 2002;45(8):1038-1042.   Published online August 15, 2002
We present a case of in-utero vesicoamniotic shunting and postnatal vesicostomy in a very low birth weight baby with posterior urethral valve syndrome. He was diagnosed as posterior urethral valve at 24＋5 weeks' gestation. Because of severe hydronephrosis and oligohydroamnios, the shunt was established by basket-shaped catheter at 27＋0 weeks' gestation. After shunt, hydronephrosis improved. At 29＋4 weeks' gestation, the...
Original Article
A Clinical Study of Children Who Showed Benign Hemophagocytic Histiocytes in Bone Marrow Examination
Jin A Park, Joo Young Park, Ji Min Park, Seat Byoul Park, Heung Sik Kim, Dong Seok Jeon
Clin Exp Pediatr. 2002;45(8):1007-1015.   Published online August 15, 2002
Purpose : The aim of this study is to find a method to diagnose and treat children who showed benign hemophagocytic histiocytes in bone marrow examination. Methods : We analyzed the clinical data of thirty patients retrospectively who showed benign hemophagocytic histiocytes in bone marrow examination from January 1995 to November 2001 at Keimyung University Dong-san Hospital. Bone marrow histiocytes...
Comparison of Two Rapid Antigen Detection Tests for Diagnosis of Group A Streptococcal Pharyngotonsillitis
Seung Kyu Song, Mi Ae Hong, Kyung Chang Oh, Seung In Ahn, Mi Hyon Tae, Hye Jung Shin, Jin Keun Chang, Sung Ho Cha
Clin Exp Pediatr. 2002;45(8):973-979.   Published online August 15, 2002
Purpose : Recently, a number of rapid antigen detection tests have been available to diagnose group A streptococcal pharyngotonsillitis. The purpose of this study was to determine the sensitivity, specificity and consistency of the two rapid antigen detection tests. Methods : Among the patients who visited our clinic from November 2001 to February 2002, 61 patients who had clinical findings of...
Case Report
A Case of Congenital Hepatic Fibrosis Accompanied by Renal Tubular Ectasia, Caroli Syndrome and Choledochal Cyst
Bong Seok Choi, Sang Nam Bae, Yong Tak Im, Jae Hong Park, Chang Hoon Lee, Jun Woo Lee
Clin Exp Pediatr. 2002;45(7):923-927.   Published online July 15, 2002
Congenital hepatic fibrosis is a relatively rare disease, characterized by bile ductular proliferation and prominent fibrosis in the portal area of liver resulting in portal hypertension. It is frequently associated with other abnormalities such as polycystic kidney, Caroli syndrome, cystic dysplasia of pancreas, intestinal lymphangiectasia, pulmonary emphysema, hemangioma, and cleft palate. We report here a case of congenital hepatic fibrosis...
Hemophagocytic Syndrome with Kawasaki Disease and Peripheral Gangrene
Hwa Jun Yun, Ko Woon Jeon, Hwang Min Kim, Seok Won Park, Young Uh
Clin Exp Pediatr. 2002;45(5):664-668.   Published online May 15, 2002
A twenty six months-old boy developed hemophagocytic syndrome during the course of Kawasaki disease. Despite the appropriate treatment modalities for Kawasaki disease, he developed thrombocytopenia, hepatomegaly, high-grade fever, hypertriglyceridemia, peripheral gangrene, and evidence of hemophagocytosis in bone marrow biopsy. Although the course was stormy, he responded well to a combination therapy of corticosteroid and etoposide.
Original Article
Study of Neonatal Cardiac Catheterization for Over the Last 10 Years
Jinyoung Song, Sungkyu Lee, Jaeyoung Lee, Sujin Kim, Wooseup Shim
Clin Exp Pediatr. 2002;45(5):615-621.   Published online May 15, 2002
Purpose : The neonatal cardiac catheterization and angiogram for transcatheter therapy are still essential methods in congenital heart disease, so we reviewed our experience with neonatal cardiac catheterization over 10 years at a single institution. Methods : A retrospective review of all 139 neonatal catheterizations from January 1991 to December 2000 at Sejong Heart Institution was performed. The purpose of the...
Therapeutic Efficacy of Cefotaxime as an Empirical Antibiotic on Ascending Cholangitis after Kasai Operation for Biliary Atresia
Dong Ho Kim, Byong Sop Lee, Yun Kyung Kim, Jae Sung Ko, Hoan Jong Lee, Jeong Kee Seo
Clin Exp Pediatr. 2002;45(4):474-481.   Published online April 15, 2002
Purpose : Ascending cholangitis is the most common complication after Kasai operations. The aim of this study is to evaluate the therapeutic efficacy of cefotaxime as an empirical antibiotic on ascending cholangitis after Kasai operations. Methods : Thirty-nine episodes of cholangitis in twenty-nine children who underwent Kasai operations at Seoul National University Children's Hospital from January 1991 to December 2000 were...
A Clinical Manifestation of Meckel's Diverticulum
Jin Beom Lee, Yong Soon Lee, Eun Sun Yoo, Hae Soon Kim, Se Jeong Son, Eun Ae Park, Seung Joo Lee, Sun Hee Sung, Jeong Wan Seo
Clin Exp Pediatr. 2002;45(4):466-472.   Published online April 15, 2002
Purpose : The diagnosis of Meckel's diverticulum is difficult and delayed because it presents with various clinical symptoms. We evaluated clinical, imaging and pathologic findings of Meckel's diverticulum to facilitate detection of Meckel's diverticulum in children. Methods : Review of clinical, imaging, surgical and pathological findings in 10 children aged 7 days to 14 years with Meckel's diverticulum during an 8-year...
Case Report
A Case of Fetal Hepatic Calcificaion with a Good Prognosis
Kyong Hee Na, Hyun Jung Lee, Sung Soo Kim, Eun Young Kim, Kyoung Sim Kim, Yong Wook Kim
Clin Exp Pediatr. 2002;45(3):395-400.   Published online March 15, 2002
Recently, the increasing use of antenatal high resolutional ultrasonographic studies, and the increasing expertise of sonographers have contributed to the more frequent prenatal detecton of fetal hepatic calcification. Fetal hepatic calcification can arise from peritoneal, ischemic, infectious, neoplastic, and idiopathic causes. There are many reports that the prognosis is good in isolated fetal hepatic calcification without chromosomal aberrations, associated congenital...
Original Article
Short-term Results of Hematopoietic Stem Cell Transplantation for Children with Myelodysplastic Syndrome
Jin Lee, Soh Yeon Kim, Bin Cho, Pil Sang Jang, Nak Gyun Chung, Hack Ki Kim
Clin Exp Pediatr. 2002;45(3):370-375.   Published online March 15, 2002
Purpose : In most cases, myelodysplastic syndrome(MDS) transforms into a more aggressive state or acute myelogenous leukemia; it's prognosis is very poor. It is believed that hematopoietic stem cell transplantation(HSCT) is the only curative treatment of MDS, but available data in children are very sparse. In this report, the short term outcome of HSCT in childhood MDS was analyzed. Methods :...
Case Report
A False Diagnosis of Hypoplastic Left Heart Syndrome in a Fetus
Youn Jeong Shin, Sung Hee Jang, Jung Yun Choi, Eun Sook Han
Clin Exp Pediatr. 2002;45(2):267-272.   Published online February 15, 2002
Typical hypoplastic left heart syndrome(HLHS) is a distinct pathologic entity with aortic atresia, mitral atresia, very hypoplastic or absent left ventricle and thread like ascending aorta. Occasionally, the lesser degree of hypoplasia is found and is called hypoplastic left heart complex(HLHC) by some authors. This HLHC is often associated with critical aortic stenosis. Fetal echocardiography has enabled us to observe...
Original Article
Megakaryocyte Colony Formation of Fetal Liver Cells
Byung O Kwon, Hye Young Ju, Chun Soo Kim, Dong Seok Jeon, Jong In Kim, Heung Sik Kim
Clin Exp Pediatr. 2002;45(2):247-255.   Published online February 15, 2002
Purpose : This study was undertaken to obtain basic data about the megakaryocyte colony formation of fetal liver cells by using immunocytochemical staining and ex vivo culture with growth factors. Methods : The mononuclear cells were isolated from fetal liver and bone marrow with idiopathic thrombocytopenic purpura(ITP) and pancytopenia. These mononuclear cells were cultured in MegaCultTM-C(Stem Cell Tech, Canada) media in...
Clinical Study of the Correlation of Tumor Necrosis Factor Alpha and the Proteinuria of Henoch-Schönlein Nephritis and Idiopathic Nephrotic Syndrome
Dong-Ho Jeong, Jeong-Hyun Park, Hye-Cheon Jeong, Hyun-Hoe Koo, Jun-Ho Lee, Tae-Sun Ha
Clin Exp Pediatr. 2002;45(2):240-246.   Published online February 15, 2002
Purpose : It is not clear that the development of glomerular injury and aggravation by tumor necrosis factor alpha(TNF-α) is related to intrarenal or serum concentration of TNF-α. So, we studied the relationship between the concentration of TNF-α and aggravation of glomerular damage in the Henoch-Schönlein nephritis(HSN) and idiopathic nephrotic syndrome(INS). Methods : We collected the sera and urines of...
Clinical Study of Renal Cystic Diseases in Children
Ja Hyung Kim, You Jeong Kim, Byeong Seon Lee, Tae Sung Ko, Young Seo Park
Clin Exp Pediatr. 2002;45(2):232-239.   Published online February 15, 2002
Purpose : Renal cystic diseases comprise a mixed group of heritable, developmental and acquired disorders. Recently the use of imaging modalities such as ultrasonography and radionuclide scanning has increased the detection rate of renal cystic diseases. We studied to review the clinical features and treatment of renal cystic diseases in children. Methods : This study was performed in 95 children with...
Changes of Body Weight and Lipid Profiles According to Apolipoprotein E Polymorphism in Children with Antiepileptics
Seung Hee Jang, Eun Kyoung Choi, So Hee Eun, Sun Jun Kim
Clin Exp Pediatr. 2002;45(1):88-94.   Published online January 15, 2002
Purpose : Weight changes, especially weight gain, is a side effect of antiepileptics(especially valproate and carbamazepine). This may be sufficiently severe to cause noncompliance or to require the withdrawal of effective treatment. Unfortunately, the exact mechanism of weight change is not illustrated. Several reports and our experiment suggested that weight gain highly correlated with a familial tendency of obesity. The genetic makeup is a...
A Nationwide Survey on the Causative Organisms of Neonatal Sepsis in Korea
Kyung Ah Kim, Son Moon Shin, Jung Hwan Choi
Clin Exp Pediatr. 2002;45(1):55-63.   Published online January 15, 2002
Purpose : A nationwide survey was conducted to investigate the most common causative organisms in neonatal sepsis in Korea. Methods : By reviewing medical records of newborn infants who were confirmed as neonatal sepsis by isolating organisms from blood culture during a one year study period from January to December in 1997, data for causative organisms, risk factors, accompanying focal infections and combinations of antibiotics...
Clinical Features of Acute Scrotum in Children
Ja Yun Yun, Mi Ran Kim, Kon Hee Lee, Kwang Nam Kim
Clin Exp Pediatr. 2001;44(12):1424-1431.   Published online December 15, 2001
Purpose : The acute scrotum is a clinical syndrome that is defined as an acute, painful swelling of the scrotum or its contents. The symptoms and signs of acute scrotum are similar and its pathognomonic features are rarely detected. This study was performed to find a proper way to diagnose and treat acute scrotum promptly and correctly. Methods : From January 1990 through December...
The Study of the Changes of Myocardial Histology and Left Ventricular Function according to the Total Doses of Doxorubicin in Rabbits
Jeong Hwa Choi, Hee Ju Park, Young Tak Lim, Bong Seon Kim, Eun Young Huh
Clin Exp Pediatr. 2001;44(12):1395-1403.   Published online December 15, 2001
Purpose : We'd like to evaluate the relationship between the degree of cardiac damage and that of cardiac function according to the total injected dose of doxorubicin. Methods : 12 rabbits(body weight : 2.0-3.2 kg) were used and 30 mg/m2/week of doxorubicin hydrochloride was injected intravenously. The cardiac function was checked under anesthesia, after which the thorax was opened and cardiac samples were evaluated...