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Original Article
Neurology
Long-term prenatal stress increases susceptibility of N-methyl-D-aspartic acid-induced spasms in infant rats
Hyeok Hee Kwon, Taekwan Lee, Jinpyo Hong, Dong Woon Kim, Joon Won Kang
Clin Exp Pediatr. 2018;61(5):150-155.   Published online May 28, 2018
Purpose

Infantile spasms, also known as West syndrome, is an age-specific epileptic seizure. Most patients with this condition also exhibit delayed development. This study aimed to determine the effect of long-term prenatal stress on susceptibility to infantile spasms.

Methods

We subjected pregnant rats to acute or chronic immobilization stress. Resulting offspring received N-methyl-D-aspartic acid (15 mg/kg, intraperitoneally) on postnatal day 15, and their...

Ictal single-photon emission computed tomography with slow dye injection for determining primary epileptic foci in infantile spasms
Yun Jung Hur, Joon Soo Lee, Hoon Chul Kang, Hye Jung Park, Mi Jin Yun, Heung Dong Kim
Clin Exp Pediatr. 2009;52(7):804-810.   Published online July 15, 2009
Purpose : We investigated whether ictal single-photon emission computed tomography (SPECT) with prolonged injection of technetium-99m (99mTc) ethyl cysteinate dimer during repeated spasms can localize the epileptogenic foci in children with infantile spasms. Methods : Fourteen children with infantile spasms (11 boys, 3 girls; mean age, 2.2¡¾1.3 years) were examined. When a cluster of spasms was detected during video electroencephalography (EEG)...
A Clinical Study on Infantile Spasms with Prednisolone Therapy
Hye Sun Yoon, Young Hoon Choi, Ho Suk Lee, Yong Mook Choi, Sa Jun Chung
Clin Exp Pediatr. 1996;39(4):522-529.   Published online April 15, 1996
Purpose : Infantile spasms are considered malignant epilepsy of infancy. Primary objectives of treatment are complete control of seizure attack and prevention of further brain damage. The aim of this study is to assess prednisolone(PDL) efficacy in infantile spasms. Methods : From June 1985 to July 1994, 20 children with infantile spasms who were diagnosed at Kyung Hee University Hospital and were...
A Clinical Study on Infantile Spasms with ACTH Therapy
Se Hee Hwang, Yong Seung Hwang
Clin Exp Pediatr. 1992;35(4):459-469.   Published online April 15, 1992
Infantile spasms is a disease, causes or treatments of which are not clearly delineated. Pri-mary objectives of treatment are complete control of seizure attack and prevention of further brain damage. Forty-one patients were managed with ACTH, who were diagnosed as infantile spasms and admitted to the Department of Pediatrics, Seoul National University Hospital from July 1985 till June 1990. The results...
2 Cases of Infantile Spasms(Cryptogenic Type) Treated with ACTH Therapy.
Shin Heh Kang, Chang Jun Coe
Clin Exp Pediatr. 1987;30(8):928-933.   Published online August 31, 1987
We have experienced 2 cases of infantile spasms treated with ACTH. They were diagnosed as cryptogenic type within relatively short duration after the onset. With the administration of ACTH, flexor spasms and hypsarrhythmia disappeared. They did not demonstrate any intellectual impair- ment on OPD follow up study. A brief review of literatures was made.
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