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Original Article
Cell Proliferation and Apoptosis in Heart of Trisomy 16 in Mice
Eun Jung Bae, Yong Soo Yun, Jung Sun Kim, Jeong-Wook Seo
Clin Exp Pediatr. 1999;42(5):621-630.   Published online May 15, 1999
Purpose : Although abnormal developments of cushion and atrioventricular septum have been suggested, the exact mechanism for the development of atrioventricular septal defect is not well known. We aimed to identify the role of cell proliferation and apoptosis on cardiac morphogenesis in trisomy 16 mice(an animal model for Down's syndrome in human). Methods : We examined the difference in cardiac...
Developmental Morphology of the Atrial Venous Component in the iv/iv Mouse
Young-Hwue Kim, Yong-Soo Yun, Jeong-Wook Seo
Clin Exp Pediatr. 1998;41(7):931-940.   Published online July 15, 1998
Purpose : Developmental processes of atria in embryos or fetuses of the iv/iv mouse were studied to find the differences between right and left atrial chambers and to identify the characteristics of atrial isomerism in the abnormal laterality syndrome. Methods : Seventy-three embryos from SI/Col iv/iv mice(Jackson's laboratory, USA) or fetuses at the 10th-13th day were used. They were examined using...


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