Clinical and Experimental Pediatrics

Editorial

Endocrinology

Rickets prevalence and treatment outcome: real-world data from Taiwan

Young Suk Shim

Clin Exp Pediatr. 2025;68(11):868-870. Published online October 23, 2025

Rickets should be recognized as a significant public health concern during infancy and childhood. Recent studies from Taiwan have demonstrated a steady increase in the prevalence of nutritional rickets, and a similar trend is likely to emerge in Korea. Therefore, comprehensive clinical evaluation and appropriate biochemical assessment are essential to prevent long-term skeletal and systemic complications. Prompt diagnosis and timely initiation of appropriate treatment are crucial.

DOI: https://doi.org/10.3345/cep.2025.01949

Review Article

Endocrinology

Genetic factors in precocious puberty

Young Suk Shim, Hae Sang Lee, Jin Soon Hwang

Clin Exp Pediatr. 2022;65(4):172-181. Published online October 18, 2021

Web of Science 30 Crossref 35

· Mutations in the kisspeptin (KISS1), kisspeptin receptor (KISS1R), makorin ring finger protein 3 (MKRN3), and delta-like homolog 1 (DLK1) genes are associated with idiopathic central precocious puberty (ICPP).
· A few genes related to pubertal onset have been implicated in ICPP.
· Epigenetic factors such as DNA methylation, histone posttranslational modifications, and noncoding ribonucleic acids may be related to ICPP

DOI: https://doi.org/10.3345/cep.2021.00521

Editorial

Endocrinology

Pediatricians must consider familial environment when diagnosing and managing childhood obesity

Young Suk Shim

Clin Exp Pediatr. 2022;65(1):31-32. Published online April 19, 2021

•The prevalence of childhood obesity is increasing worldwide, including in the Republic of Korea, creating a major public healthissue.
•Accumulated evidence indicates a strong relationship between parentalandchildobesity.
•A family-based approach is indicated to prevent and manage childhoodandadultobesity.

DOI: https://doi.org/10.3345/cep.2021.00318

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