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A Clinical Aspect of the Hemolytic Uremic Syndrome

Journal of the Korean Pediatric Society 1992;35(7):909-920.
Published online July 15, 1992.
A Clinical Aspect of the Hemolytic Uremic Syndrome
Hye Won Park, Tae Sun Ha, Il Soo Ha, Hae Il Cheong, Yong Choi, Kwang Wook Ko
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
용혈성 요독 증후군에 관한 임상적 고찰
박혜원, 하태선, 하일수, 정해일, 최용, 고광욱
서울대학교 의과대학 소아과학교실
Abstract
We reviewed the medical records of 14 children (8 girls, 6 boys), diagnosed as hemolytic uremic syndrome at Seoul National University Children뭩 Hospital from 1981 to 1990. The age at presentation ranged from 1 month to 10 years, with a mean age of 2.7 years. Only eight (57.1%) of the children had diarrheal prodrome and five (35.7%) had grossly bloody stool. Oligoanuria developed in eight (57.1%) and gross hematuria in eight (57.1%). Six (42.9%) chlidren had seizures and alteration of consciousness occurred in five (35.7%). In six children (42.9%) serum uric acid levels greater than 15mg/dl were observed. Hypocomplementemia was noted in six (60.0%) of the ten children who had been measured. No organism grew in stool culture for Salmonella and Shigella from 5 diarrheal children. Overall outcome was poor. Of the 14 children, only five (35.7%) recovered their renal function completely. Hypertension with proteinuria or microscopic hematuria persisted after recovery from renal failure in three (21.4%). Four (28.6%) progressed to end-stage renal disease requiring dialysis and one (7.1%) slowly developed renal insufficiency. One (7.1%) died of acute renal failure.
Key Words: Hemolytic uremic syndrome


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