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A Case of Successful Treatment of Pulmonary Alveolar Hemorrhage with Plasmapheresis in Child with Systemic Lupus Erythematosus

Journal of the Korean Pediatric Society 1998;41(7):974-978.
Published online July 15, 1998.
A Case of Successful Treatment of Pulmonary Alveolar Hemorrhage with Plasmapheresis in Child with Systemic Lupus Erythematosus
Jae Hong Min1, Kyung Hoon Paek1, Kyung Mi Park1, Jin Soon Hwang1, Jung Sue Kim1, Il Soo Ha1, Hae Il Cheong1, Kyou Seup Han2, Yong Choi1
1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
2Department of Clinical Pathology, Seoul National University College of Medicine, Seoul, Korea
폐출혈이 동반된 전신성 홍반성 낭창 환아에서 혈장 교환술을 이용한 성공적인 치료 경험 1례
민재홍1, 백경훈1, 박경미1, 황진순1, 김정수1, 하일수1, 정해일1, 한규섭2, 최용1
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 임상병리학교실
Abstract
Seoul National University College of Medicine, Seoul, Korea Pulmonary hemorrhage is a rare but possibly fatal complication of systemic lupus erythematosus(SLE). We report a case of massive pulmonary hemorrhage in a 14-year-old boy recently diagnosed as SLE. He developed massive pulmonary hemorrhage during the courses of i.v. methylprednisolone pulse therapy, and did not respond to i.v. cyclophosphamide. However, he rapidly improved through the use of plasmapheresis. Although various factors can precipitate pulmonary hemorrhage in SLE, our case was probably caused by an immune mediated mechanism since the hemorrhage responded promptly to plasmapheresis. This case illustrates the importance of plasmapheresis in the treatment of pulmonary hemorrhage which is not improved by methylprednisolone and cyclophosphamide. We report this case with a brief review of the related literatures.
Key Words: Pulmonary hemorrhage, Systemic lupus erythematosus(SLE), Plasmapheresis


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