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Effect of Low-Dose Aspirin Therapy on Platelet Aggregation in Kawasaki Disease

Journal of the Korean Pediatric Society 1999;42(4):510-518.
Published online April 15, 1999.
Effect of Low-Dose Aspirin Therapy on Platelet Aggregation in Kawasaki Disease
Ju Yeon Yeo1, Heon Eui Le1, Young Mi Hong1, Ki Sook Hong1, Wha Soon Chung2
1Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea
2Department of Clinicopathology, College of Medicine, Ewha Womans University, Seoul, Korea
가와사끼병에서 저용량 아스피린 치료가 혈소판 응집에 미치는 영향
여주연1, 이현의1, 홍영미1, 홍기숙1, 정화순2
1이화여자대학교 의과대학 소아과학교실
2이화여자대학교 의과대학 임상병리학교실
Correspondence: 
Young Mi Hong, Email: 1
Abstract
Purpose
: Aspirin(acetylsalicylic acid) has been used to treat unstable angina and acute myocardial infarction in adults and Kawasaki disease in children. The antithrombotic effect of aspirin was attributed to its ability to inhibit platelet aggregation by inhibiting platelet cyclooxygenase, which leads to decreased thromboxane synthesis. The purpose of this study was to evaluate the effect on the platelet aggregation by low dose aspirin in Kawasaki patients and to learn the side effects of low-dose aspirin.
Methods
: Fifty patients with Kawasaki disease who were treated with low-dose aspirin, and 22 normal children were studied from Jan. 1996 to Dec. 1997. The platelet count, bleeding time, clotting time, platelet aggregation test(induced by ADP, epinephrine, collagen and ristocetin) and blood aspirin level by colorimetric method were checked.
Results
: The platelet count, bleeding time, and clotting time in the patient group were not significantly different from the control group. The mean maximum platelet aggregation was 54.4¡¾12.8% induced by ADP, 15.9¡¾11.7% by epinephrine, 55.5¡¾23.8% by collagen, 52.6¡¾32.2% by ristocetin in the patient group. It was significantly lower than the control group(P<0.05). The mean blood aspirin level in the patient group was 5.4¡¾3.7mg/dl. Side effects of low-dose aspirin were bruise, epistaxis and hematuria.
Conclusion
: Low-dose aspirin therapy in patients with Kawasaki disease inhibited platelet aggregation, but attention would be needed because of the tendency to bleed in these patients. Further investigations should be focused on the subject such as the onset of the maximal antiplatelet effect and time needed for the recovery of platelet function.
Key Words: Low dose aspirin, Platelet aggregation, Kawasaki disease


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