| Diagnostic Value of Urine Latex Test In Bacterial Meningitis |
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Seung Min Lee, Eun Ae Park, Seung Joo Lee |
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Department of Pediatrics, Ewha Womans University, College of M edicine, Seoul, Korea |
| 세균성 뇌막염에서 소변 Latex 검사의 진단적 가치 |
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이승민, 박은애, 이승주 |
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이화여자대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: Bacterial meningitis in childhood carries significant mortality and morbidity, so accurate
and rapid diagnosis is important. Cerebrospinal fluid(CSF) latex agglutination test has been used
for rapid diagnosis of bacterial meningitis. However, urine may be the best specimen for a latex
test, because bacterial antigens are concentrated in the urine. The study tried to determine the
diagnostic value of urine latex test in bacterial meningitis.
Methods
: We evaluated 219 patients who were suspected with bacterial meningitis and examined
CSF Gram stain, CSF culture, CSF latex test and urine latex test. And 17 patients with bacterial
meningitis were followed up at post-antibiotics 3, 7, 14, 21, 28 days.
Results
: Sensitivity and specificity of urine latex test in bacterial meningitis were 82.4% and
99.4%. In H. influenzae type b meningitis, the sensitivity and specificity of urine latex test were
100% and 99.4%. The positive rates of urine latex tests after antibiotics treatment persisted
significantly longer than the positive rates of CSF culture, smear and latex test.
Conclusion
: Urine latex test was as useful as CSF smear and CSF latex test during the early
diagnosis of bacterial meningitis. The urine latex test was more valuable than CSF smear, latex,
and culture in partially treated bacterial meningitis, because of persistent positivity after
antibiotics treatment. |
| Key Words:
Bacterial meningitis, CSF latex, CSF smear |
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