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Effects of Vigabatrin on Pilocarpine-Induced Seizures in Immature Rats

Journal of the Korean Pediatric Society 2001;44(2):185-192.
Published online February 15, 2001.
Effects of Vigabatrin on Pilocarpine-Induced Seizures in Immature Rats
Bo Ram Choe, In-Goo Lee, Kyung-Tae Whang
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea
어린 흰쥐에서 Pilocarpine에 의해 유발된 경련에 대한 Vigabatrin의 효과
최보람, 이인구, 황경태
가톨릭대학교 의과대학 소아과학교실
In-Goo Lee, Email: iglee@cmc.cuk.ac.kr
: Vigabatrin is a widely used antiepileptic drug that greatly increases whole brain γ- aminobutyric acid(GABA). But little is known about the anticonvulsant effect of vigabatrin on pilocarpine-induced seizures in the immature rats. This study was conducted to determine the effects of vigabatrin on pilocarpine-induced seizures in the immature rats.
: Six to eight day old Sprague-Dawley rats were classified into control(n=5) and vigabatrin-treated(n=5) groups that were pretreated with 30mg/kg of vigabatrin. Animals received vigabatrin or saline, intraperitonealy, for 6 days, once a day. And on the 5th day, right and left cortical electrodes were placed in 10-14 day old animals using stereotaxic instrument. The following day 2.5-hour EEG recordings were obtained to monitor the latency to first electrographic seizures and to first status epilepticus induced by intraperitoneal injection of pilocarpine(200mg/kg). Data were analyzed using the log-rank test.
: Electrographic seizures and status epilepticus were seen in 80% of vigabatrin-treated group, and in 100% of control group rats. And the latency to first seizure was 8.8±2.0 minutes in control group and 20.5±5.2 minutes in vigabatrin-treated animals(P<0.02), and to status epilepticus was 12.2±1.2 minutes in control group and 29.3±6.3 minutes in vigabatrin-treated group(P<0.03).
: It was confirmed that 30mg/kg of vigabatrin administration for 6 days did not affect the body weight gain and behavior of immature rats and had an anticonvulsant effect. These findings might demonstrate that the prolonged latency to seizure, and to status epilepticus, was a time to reduce GABA that was elevated in the brain by vigabatrin administration below the seizure threshold, by pilocarpine.
Key Words: Vigabatrin, Pilocarpine-induced seizures, Immature rats

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