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Effect of Adriamycin on Lipid Metabolismin Rats.

Journal of the Korean Pediatric Society 1988;31(9):1133-1138.
Published online September 30, 1988.
Effect of Adriamycin on Lipid Metabolismin Rats.
Chang Beom Shin, Sun Jun Kim, Chan Unng Joo, Dae Yeol Lee, Jung Soo Kim
Department of Pediatrics, Chonbuk National University, Medical School, Chonju, Korea
백서에서 Adriamycin이 지질대사에 미치는 영향
신창범, 김선준, 주찬웅, 이대열, 김정수
전북대학교 의과대학 소아과학교실
Received: 1 February 1988   • Accepted: 24 March 1988
Abstract
This experiment was carried out to investigate the disturbance of lipid metabolism after long-term administration of adriamycin in rats (2.5 mg/kg/week for 5 weeks, S.C.). Changes of Serum lipids, GOT, GPT, LDH, albumin, BUN, and creatinine were investigated after administration of adriamycin. Clinical findings of congestive heart failure and changes of body weight were also observed during experiment. The results were as follows; 1) Serum triglyceride, total cholesterol, free cholesterol, HDL cholesterol were makkedly elevated after administration of adriamycin. 2) No significant differences were found in serum GOT, GPT, LDH, albumin, BUN, creatinine between control and adriamycin administered group. 3) All classes of lipoproteih were increased after administration of adriamycin compose to that of control group on lipoprotein electrophoretic analysis. 4) Symptoms and sings of congestive heart failure (tachypnea, ascites, hepatomegaly) were appeared in 6 rats (43%) in experimental group. These results suggest that adriamycin-induced cardiotoxicity is related to disturbance of lipid metabolism in rats.
Key Words: Adriamycin, Lipid Metabolism


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