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Comparison of Eosinophil Markers between Acute and Recovery Stages in Children with Mycoplasma pneumoniae Pneumonia

Journal of the Korean Pediatric Society 2002;45(10):1227-1233.
Published online October 15, 2002.
Comparison of Eosinophil Markers between Acute and Recovery Stages in Children with Mycoplasma pneumoniae Pneumonia
Kyu Min Nah1, Eun Kyeong Kang1, Hee Kang1, Yang Park2, Young Yull Koh2
1Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
2Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
Mycoplasma pneumoniae 폐렴 환아에서 급성기 및 회복기의 호산구 지표의 비교
나규민1, 강은경1, 강 희1, 박 양2, 고영률2
1서울대학교 의과대학 소아과학교실
2원광대학교 의과대학 군포병원 소아과
Correspondence: 
Young Yull Koh, Email: kohyy@plaza.snu.ac.kr
Abstract
Purpose
: Several studies have shown that increases of eosinophil markers are common findings of asthma and Mycoplasma pneumoniae infection, and eosinophil markers reflect the clinical stage of asthma. The purpose of this study was to investigate the change of eosinophil markers according to the clinical stage of Mycoplasma pneumonia.
Methods
: The patient group consisted of 33 outpatient children with Mycoplasma pneumonia. Peripheral blood total eosinophil count(TEC) and serum eosinophilic cationic protein(ECP) level were measured at both acute and recovery stages and were compared between both stages. The patient group was subdivided into the wheezing(n=16) and the nonwheezing group(n=17), and the TECs and the ECPs of one group were compared with those of the other group. The correlation between Mycoplasma antibody titer and the eosinophil markers of acute stage were analyzed.
Results
: In the whole patient group, the TECs and the ECPs of the acute stage were significantly higher than those of the recovery stage(P=0.018, P=0.005), but there were no differences in the TEC and the ECP between the wheezing and the nonwheezing group. In the wheezing group, there were no significant differences in the TEC and the ECP between acute and recovery stages. There were no correlations between acute stage Mycoplasma antibody titer and the eosinophil markers.
Conclusion
: Eosinophil markers reflect the clinical stage of Mycoplasma pneumonia and eosinophilic inflammations may continue even after the acute stage in wheezing patients with Mycoplasma pneumonia.
Key Words: Mycoplasma pneumoniae, Pneumonia, Eosinophils, Wheezing


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