| Experimental Study for the Teratogenic Effect of Gamma-ray on the Heart of Chick Embryo |
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Yong Whan Jo1, Nam Su Kim1, Sung Yup Moon1, Myeng Gul Yum1, Sung Hoon Kim2, Ha Chung Chun2, Yong Joo Kim1, Hahng Lee1 |
1Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea
2Department of Radiotheraphy, College of Medicine, Hanyang University, Seoul, Korea |
| 계태에서 감마선 조사에 의한 심장기형 발생에 관한 실험적 연구 |
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조용환1, 김남수1, 문성엽1, 염명걸1, 김성훈2, 전하정2, 김용주1, 이항1 |
1한양대학교 의과대학 소아과학교실
2한양대학교 의과대학 치료방사선과학교실 |
Correspondence:
Nam Su Kim, Email: namsukim@hanyang.ac.kr
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| Abstract |
Purpose
: To investigate the teratogenic effect of gamma-ray on the heart of chick embryo.
Methods
: 50 rad, 100 rad, 150 rad, 200 rad, 250 rad, and 300 rad of gamma-ray were used to irradiate three days old chick embryos. The control group was not irradiated. After three weeks, the embryos were sacrificed and examined for cardiovascular malformation.
Results
: The survival rate of the gamma-ray irradiated group was significantly lower than that of the control group(33.3-63.3% vs 76.4%, P=0.001). The cardiac malformation rate of the experimental group was 11.0%. In the control group, no congenital cardiac malformations were observed. The experimental groups had a significantly higher malformation rate(P=0.001). The types of malformation were ventricular septal defect, tricuspid atresia, Ebstein anomaly and aortic arch anomaly. In the gamma-ray irradiated group, the cardiac malformations were : 14 small ventricular septal defects (VSDs), five large VSDs, two tricuspid atresias, and one Ebstein anomaly. The higher the dose of radiation applied, the higher the incidence of cardiac malformation was noted.
Conclusion
: Gamma-ray irradiation of 3 days old chick embryos increased the rate of death and the rate of cardiac malformation significantly. |
| Key Words:
Gamma-ray, Chick embryo, Cardiac malformation |
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