| Cytokines in Neonatal Sepsis |
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Hye Jin Park1, So Yeon Kim1, Jun Hwa Lee1, Eun Jin Choi1, Jin Kyung Kim1, Sang Gyung Kim2, Hai Lee Chung1, Woo Taek Kim1 |
1Department of Pediatrics, School of Medicine, Catholic University of Daegu, Daegu, Korea
2Department of Pediatrics, School of Medicine, Catholic University of Daegu, Daegu, Korea |
| 신생아 패혈증에서 Cytokine치들의 의의 |
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박혜진1, 김소연1, 이준화1, 최은진1, 김진경1, 김상경2, 정혜리1, 김우택1 |
1대구가톨릭대학교 의과대학 소아과학교실
2대구가톨릭대학교 의과대학 진단검사의학교실 |
Correspondence:
Woo Taek Kim, Email: wootykim@cu.ac.kr
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| Abstract |
Purpose
: Maternal premature rupture of membrane(PROM) over 24 hours is a risk factor in neonatal sepsis and a main cause of administration to neonatal intensive care unit. Levels of proinflammatory cytokines were studied to diagnose and treat early in newborn infants with sepsis and with a history of maternal PROM.
Methods
: Interleukin-1β(IL-1β), Interleukin-6(IL-6), Interleukin-8(IL-8), and tumor necrosis factor-α(TNF-α) were checked using ELISA kits in neonatal infants who were admitted to the Catholic University of Daegu from May, 2002 to Feb, 2003. We divided them into three sets of groups; sepsis group(n=26), PROM group(n=20), and control group(n=24).
Results
: Levels of IL-1β, IL-8, and TNF-α in the sepsis group were all significantly statistically different from the PROM and the control group, but there was no significant difference between the PROM group and the control group. Levels of IL-6 in the sepsis, the PROM, and the control group were all significantly statistically different from each other.
Conclusion
: Levels of IL-1β, IL-6, IL-8, and TNF-α in the sepsis group increased but only levels of IL-6 in the PROM group increased. Thus we can use cytokines as a marker of neonatal sepsis, especially, in neonatal infants with a history of maternal PROM. |
| Key Words:
Sepsis, Interleukin-1β, Interleukin-6, Interleukin-8, TNF-α, Premature rupture of membrane |
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