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Immune response induced by live attenuated varicella vaccine(Biken@) in children with acute lymphoblastic leukemia.

Journal of the Korean Pediatric Society 1991;34(9):1255-1260.
Published online September 30, 1991.
Immune response induced by live attenuated varicella vaccine(Biken@) in children with acute lymphoblastic leukemia.
Hyo Seop Ahn, Joong Gon Kim
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
약독화된 생수두백신 접종에 따른 급성 림프구성 백혈병 환아에서의 면역학적 반응
안효섭, 김중곤
서울대학교 의과대학 소아과학교실
Received: 3 May 1991   • Accepted: 2 June 1991
Abstract
To determine the safety and efficacy of varicella vaccine, we studied 10 healthy children and 12 children in remission from acute lymphoblastic leukemia. They were immunized with the Oka strain of live attenuated varicella vaccine (Biken®). All the healthy children and 6 children with leukemia received the vaccine of 1,000 plaque-forming units (PFU), and 6 leukemic children received the vaccine of 500 PFU. The antibody titers were measured before and 6 weeks after immunization with use of enzyme immunoassay. Seroconversion occurred in 90% of the 10 healthy children, 83% of 6 leukemic children receiving the vaccine of 1,000 PFU and 33% of 6 leukemic children receiving the vaccine of 500 PFU. The rashes and vesicles related to immunization were observed in 33% of leukemic children receiving the vaccine of 1,000 PFU and in 11% of leukemic children receiving the vaccine of 500 PFU. The rashes and vesicles were observed almost 25~26 days after the immunization. These reactions were not fatal or were not associated with the relapse of leukemia. The rashes were not observed in all the healthy children. Chickenpox has been documented in 2 seropositive children, one healthy child (11%) and one leukemic child receiving the vaccine of 1,000 PFU (20%). We conclude that varicella vaccine is safe and induces an immunity to chickenpox.
Key Words: Live Attenuated Varicella Vaccine, Acute Lymphoblastic Leukemia, Immunization, Chickenpox


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