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Clinical study on lipoid pneumonia caused by aspiration of squalene.

Journal of the Korean Pediatric Society 1991;34(5):654-661.
Published online May 31, 1991.
Clinical study on lipoid pneumonia caused by aspiration of squalene.
Dong Joo Shin1, Beom Soo Park1, Moon Sun Yang1, Heon Seok Han1, Young Yull Koh1, Hyung Ro Moon1, Chang Yeon Lee2
1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
2Department of Pediatrics, Dongkuk University College of Medicine, Kyungjoo, Korea
스쿠알렌 흡인에 의하여 유발된 지방성 폐렴에 관한 임상적 관찰
신동주1, 박범수1, 양문선1, 한헌석1, 고영률1, 문형로1, 이창연2
1서울대학교 의과대학 소아과학교실
2동국대학교 의과대학 소아과학교실
Received: 19 September 1990   • Accepted: 30 November 1990
A clinical observation was made on 14 cases of lipoid pneumonia, who visited department of pediatrics, Seoul National University Children’s Hospital from August, 1988 to June, 1990. The results were as follows; The ratio of male to female was 10 : 4. Age at diagnosis was 1.1±1. 3 years, and ranged from 3 months to 4.9 years. The age at taking Squalene ranged from 5 days to 3 years 1 month of age. The interval between taking Squalene and the onset of symptoms was 28.4 ± 6.0 days. Chief complaints were cough (10 cases), fever (7 cases), tachypnea (7 cases), dyspnea (1 case), and irritability (1 case). The duration of admission till diagnosis as lipoid pneumonia was 79 days in the longest case. In 9 of 14 cases (64.3%), previous or underlying diseases were present, such as bacterial pneumonia (2 cases), menigitis (2 cases), achondroplasia, congenital muscular dystrophy, acute myelogenous leukemia, coarctation of aorta, and neuroblastoma. Patients usually took three capsules a day, which was increased up to 70 capsules maximally a day. Most of the patients took the medication in supine position, and the remainder in sitting position. Squalene was administrated in liquid form. Chest retraction was present in 11 cases, and no rale was heared in 13 cases. The respiratory rates were high for ages in all cases. Tuberculin test was negative in all cases. Hypertran- saminasemia was present in 12 cases (85.7%), but its significans was not explained. In chest X-ray, right uper lung was most severely affected, and right lower lung and left lower lung were affected also. In one case, atelectasis was present. In conclusion, lipoid pneumonia should be suspected when uncertain type of pneumonia is present in infants on lipoid substance.
Key Words: Lipoid pneumonia, Squalene

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