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Clinical Bacteriologic Study of Serratia Marcescens Septicemia.

Journal of the Korean Pediatric Society 1987;30(12):1409-1418.
Published online December 31, 1987.
Clinical Bacteriologic Study of Serratia Marcescens Septicemia.
Hyo Sook Hong, Wan Seob Kim, Oh Kyung Lee, Myung Ho Lee
Department of Pediatrics. Chonju Presbyterian Medical Center
Serratia Marcescens 패혈증의 집단발병에 대한 임상적 세균학적 연구
홍효숙, 김완섭, 이오경, 이명호
전주예수병원 소아과
We experienced an outbreak of Serratia marcescens septicemia during a 2-month-10-day period (Apirl the 10th, 1985-June the 6th, 1985) in the Chonju Presbyterian medical center, pediatric ward. The clinical and bacteriological features of 22 patients with septicemia were described. There were 25 bacterial isolates from 22 patients. Twenty cases of 22 patients recovered, while 2 patients died, both premature infants. This indicated the seriousness of the outbreak. Analysis of this experience confirmed the importance of factors associated with Serratia infection: 1) Age Twelve cases (54%) occured in neonates. 2) Immunosuppressive therapy or immunocompromise of the host. There were three cases in immunocompromised patients over the age of three years; all were receiving immunosuppressive therapy. The organisms isolated were resistant to many antibiotics including ampicillin, carbenicillin, cephalothin, tetracycline, gentamicin and kanamycin. Nevertheless, they were most sensitive to amikacin, chrolamphenicol, moxalactam, cefotaxim and cefobid. Environmental surveys incriminated contaminated intravenous fluids as the “common source”. Complete termination of the outbreak took place after control measures were instituted. This report demonstrates that intravenous therapy may be associated with an increased risk of life-threatening septicemia.
Key Words: Serratia marcescens septicemia

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